Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2

By L. Abu-Elheiga, M. Matzuk, K. Abo-Hashema, S. Wakil. Science, 2001

927 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/fd6ac5418e75b2b7559b16e1a25b07ba9b693509

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. David Carling

In Molecular Biology

1. David Carling
2. D. Moller
3. B. Kahn
4. Russell G. Jones
5. M. Poffenberger
6. Erika L. Pearce
7. Chih-Hao Chang
8. D. Hardie

In Physiology

1. David Carling
2. D. Moller
3. B. Kahn
4. Erika L. Pearce
5. Shannon M. Reilly
6. Ralph DeFronzo
7. M. Buchheit

Citations in the corpus

• Myocardial substrate metabolism in the normal and failing heart. (2005, background): “A fall in malonyl-CoA increases fatty acid uptake and oxidation (2, 143, 236), and an increase suppresses fatty acid oxidation (390, 430).”
• The Human Obesity Gene Map: The 2005 Update (2006, background): “1 ACACB Acetyl CoA carboxylase , also known as Acc2 Reduced adiposity; resistant to dietinduced obesity (272,273)”
• New drug targets for type 2 diabetes and the metabolic syndrome (2001, background): “ACC is also an exciting independent drug target, as mice deficient in one of two main ACC isoforms (ACC2) were characterized by increased fatty-acid oxidation with markedly reduced body weight and adiposit”
• Knockouts model the 100 best-selling drugs—will they model the next 100? (2003, background): “By histopathological analysis, Acac2 −/− mice had fewer lipid droplets in their livers than wild-type mic”
• Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, neutral): “Recent studies of brain mitochondria isolated from streptozotocin-treated rats revealed decreased respiration during state 3 and state 4, with no change in the ADP = O ratio (223), raising the possibility of impaired electron transport or ATP synthase.”
• Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. (2008, background): “ACC2 is known to suppress fatty acid catabolism (Abu-Elheiga et al., 2001).”