Paul Ehrlich's magic bullet concept: 100 years of progress
By K. Strebhardt, A. Ullrich. Nature Reviews. Cancer, 2008
1,327 citations recorded by the source corpus.
Subfields: Oncology, Public Health, Environmental and Occupational Health, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/fd4de6ff71812c62f0f6f8e918c947893ba41212
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Citations in the corpus
- Recent Advances in Aptamer Discovery and Applications (2019, neutral): “Target-specific therapy was discovered by the inventor of chemotherapy, Paul Ehrlich [1].”
- Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “More than 40 years ago, the foundations were laid down for nanotechnologies to deliver therapeutic and diagnostic agents in a safer and more efficient manner [1].”
- Targeted drug delivery to tumors: Myths, reality and possibility (2011, neutral): “Therefore, a more realistic interpretation of the “magic bullet” concept is for a compound that interacts with its target in an exclusive, highly specific fashion [12].”
- The safety and side effects of monoclonal antibodies (2010, background): “jpg"/> In 1975, Kohler and Milstein published their seminal manuscript on hybridoma technology enabling the production of mouse monoclonal antibodies (mAbs”
- Current trends in the use of liposomes for tumor targeting (2013, background): “The concept of targeting liposomes to tumor sites was derived from Ehrlich's concept of a `magic bullet' coined in 1906 [2].”
- Antibody Drug Conjugates for Cancer Therapy (2016, background): “3 by guest on July 11, 2021 D ow nloaded from I. Introduction Most reviews on antibody drug conjugates (ADCs) begin by citing Paul Ehrlich’s prophetic "magic bullet" proposal from 1908 (Strebhardt and Ullrich, 2008).”
- Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (2010, result): “This development is fuelled by previous pharmaceutical and clinical investigations, which had convincingly shown that antimitotic drugs are successful chemotherapeutic tools for the fight against cance”
- Antibody drug conjugate: the “biological missile” for targeted cancer therapy (2022, background): “As early as the beginning of 20th century, Paul Ehrlich first proposed the concept of “magic bullets” and postulate that some compounds could directly access to some desired targets in cell to cure diseases.(9) Theoretically, these compounds should be effective in killing cancer cells, but harmless ”
- Targeted delivery of low molecular drugs using chitosan and its derivatives. (2010, background): “The idea of developing a drug that selectively destroy disease cells without damaging healthy cells was proposed by Paul Ehrlich, almost a century ago; he called his hypothetical drug the “magic bullet” [5].”