Targeted delivery of low molecular drugs using chitosan and its derivatives.

By J. Park, G. Saravanakumar, Kwangmeyung Kim, I. Kwon. Advanced Drug Delivery Reviews, 2010

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Recent advances of chitosan nanoparticles as drug carriers (2011, background): “35 Ethylene chitosan nanoparticles had a prolonged circulating time in the blood with a high tumor-cell selectivity.”
Polysaccharide-Based Hydrogels: The Key Role of Water in Affecting Mechanical Properties (2012, background): “Among its applications, mention should be made of chitosan’s use as a hypocholesteremic and bacteriostatic agent, as a drug carrier or as a scaffold for cell cultures [16,17].”
Effects of ionic strength on the size and compactness of chitosan nanoparticles (2012, background): “Chitosan nanoparticles crosslinked with TPP (chitosan–TPP nanoparticles) have been employed in drug delivery of both small molecular drugs, like estradiol and venlafaxine, and macromolecules, such as insulin and DNA [4, 13, 17, 19–27], and is thus a promising nanoparticulate drug delivery system.”
Chitosan—A versatile semi-synthetic polymer in biomedical applications (2011, background): “chitosan as a carrier for various active agents [293–295].”
Biological activities of chitosan and chitooligosaccharides (2011, background): “Chitosan can accelerate the absorption of calcium and iron, and the chelation of metal ions may also be related to its drugdelivery characteristics (Liao et al., 2007; Park et al., 2010), but there is some disagreement on this point.”