CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

By P. Kirk, Marieangela C. Wilson, Catherine Heddle, Marion H. Brown, A. Barclay, A. Halestrap. EMBO Journal, 2000

713 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fbf54f9e16bd0ec73b18bbad81d75869c1c38142

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A. Halestrap

Citations in the corpus

Monocarboxylate transporters in the central nervous system: distribution, regulation and function (2005, background): “MCT2 did not interact with CD147, although its expression at the cell surface also requires an ancillary protein, not yet identified (Kirk et al. 2000).”
Targeting lactate metabolism for cancer therapeutics. (2013, background): “Specifically, MCT1, MCT3, and MCT4 bind to CD147 (also known as basigin, EMMRIN, and OX-47), which is required for their expression on the cell surface, whereas MCT2 binds and requires embigin for cell surface expression (60, 61).”
The SLC16 gene family - structure, role and regulation in health and disease. (2013, background): “These proteins act as chaperones and in their absence MCTs1–4 fail to reach the plasma membrane and are accumulated in the Golgi apparatus (Kirk et al., 2000; Wilson et al., 2005).”
The monocarboxylate transporter family—Structure and functional characterization (2012, background): “basigin both MCT1 and MCT4 were correctly targeted to the plasma membrane, suggesting that basigin acts as an essential chaperone for both MCTs (48).”
The SLC16 gene family—from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond (2004, background): “Only when CD147 is co-expressed with MCT1 or MCT4 are both proteins correctly targeted to the plasma membrane rather than accumulating in the endoplasmic reticulum/Golgi apparatus [34].”
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “The hypoxia-induced monocarboxylate transporter MCT4, the constitutively expressed MCT1 and their chaperone CD147 are key plasma-membrane proteins involved in pH regulation, energy balance, tumour progression and metastasis Among the 14 MCT isoforms, only MCT1, MCT2, MCT3 and MCT4 have been demonstr”