Monocarboxylate transporters in the central nervous system: distribution, regulation and function

By K. Pierre, Luc Pellerin. Journal of Neurochemistry, 2005

698 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/9b44da147b071b6ef06236561b14067b1d956e6c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Igor Allaman
2. Pierre J. Magistretti
3. Angus M. Brown
4. A. Halestrap
5. Marieangela C. Wilson
6. B. Ransom
7. M. Sofroniew
8. G. Dienel

In Endocrine and Autonomic Systems

1. Pierre J. Magistretti
2. Igor Allaman

In Physiology

1. Pierre J. Magistretti
2. Luc Pellerin
3. Igor Allaman
4. A. Halestrap
5. Marieangela C. Wilson

Citations in the corpus

• Astrocyte glycogen and brain energy metabolism (2007, background): “Indeed neurons and axons possess the MCT subtype (MCT2) expressed in tissue that take up lactate (Bergersen et al., 2005; Pierre and Pellerin, 2005; Pierre et al., 2000) as well as the lactate dehydrogenase subtype that preferentially converts lactate to pyruvate (Bittar et al., 1996), prior to…”
• Astrocyte-neuron lactate transport is required for long-term memory formation (2011, neutral): “In the brain, the MCT1 is expressed mainly in endothelial cells of microvessels, ependymo- 814 Cell 144, 810–823, March 4, 2011 ª2011 Elsevier Inc. cytes astrocytes and oligodendrocytes but not in neurons, whereas the MCT4 is expressed virtually exclusively in astrocytes (Pierre and Pellerin, 2005).”
• Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters (2007, background): “These and subsequent studies have shown MCT2 to be extensively expressed in dendrites and associated with postsynaptic densities (Bergersen et al, 2005; Pierre et al, 2002; Pierre and Pellerin, 2005).”
• A cellular perspective on brain energy metabolism and functional imaging. (2015, background): “Glycolytically derived pyruvate is converted to lactate by lactate dehydrogenase 5 (mainly expressed in astrocytes) and shuttled to neurons through monocarboxylate transporters (mainly MCT1 and MCT4 in astrocytes and MCT2 in neurons).”
• The monocarboxylate transporter family—Role and regulation (2012, background): “Consistent with this, MCT2 expression in the brain is largely confined to the postsynaptic density (PSD) of the neurons, a region rich in mitochondria and thought to oxidize lactate as a preferred respiratory fuel (9).”
• Sweet Sixteen for ANLS (2012, background): “In recent years, a precise description of the expression and distribution of monocarboxylate transporters in the central nervous system has been provided by immunohistochemical studies (reviewed in Pierre and Pellerin, 2005).”
• BRAIN FUEL METABOLISM, AGING AND ALZHEIMER’S DISEASE (2010, background): “Several MCTs are expressed in the brain [165] and their expression responds positively to raised plasma ketones [162].”