Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

By Y. Minokoshi, Young-Bum Kim, O. Peroni, L. Fryer, C. Müller, David Carling, B. Kahn. Nature, 2002

2,108 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Surgery

View Paper: https://www.semanticscholar.org/paper/fbf441578acd14df5d3f646845641d6dbd613981

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Haiming Cao
2. D. Hardie
3. G. Frühbeck
4. Herbert Tilg
5. P. Scherer
6. Toshimasa Yamauchi
7. B. Kahn
8. Sushil Kumar Jain

In Nutrition and Dietetics

1. D. Hardie
2. Haiming Cao
3. Toshimasa Yamauchi
4. B. Kahn
5. Sushil Kumar Jain
6. Prasenjit Manna
7. Takashi Kadowaki
8. B. K. Pedersen

In Surgery

1. D. Hardie
2. David Carling
3. S. Hawley
4. B. K. Pedersen
5. Bruce E. Kemp
6. Haiming Cao
7. K. Green
8. J. Scott

Citations in the corpus

• CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. (2004, background): “It is also activated by the antidiabetic drugs metformin and rosiglitazone (21–23), and by the adipocyte-derived hormones leptin and adiponectin (24, 25).”
• Intracellular signalling pathways activated by leptin. (2006, background): “However, the signalling elements counteracting lipotoxicity were not fully understood until some years ago when a novel pathway participating in leptin’s action on metabolism was identified [140].”
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, neutral): “, 2000) and skeletal muscle (Minokoshi et al., 2002).”
• Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. (2007, background): “…(AMPK) plays a key role in the regulation of energy homeostasis (Hardie, 2004; Carling, 2005; Luo, et al., 2005) and has recently been found to mediate the stimulation of fatty acid oxidation induced by leptin (Minokoshi et al., 2002) and adiponectin (Yamauchi et al., 2002) in skeletal muscle.”
• Adiponectin and adiponectin receptors. (2005, background): “Because leptin has also been shown to stimulate AMPK in skeletal muscle (54), activation of AMPK may be a common mechanism by which insulin-sensitizing adipokines such as adiponectin and leptin increase insulin sensitivity.”
• AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “Both leptin (Minokoshi et al. 2002) and adiponectin (Yamauchi et al.”
• Adipokines: the missing link between insulin resistance and obesity. (2008, background): “On the other hand, eptin improves insulin sensitivity through activation of AMP rotein kinase (AMPK), which controls cellular concentrations f malonyl-CoA, thereby inhibiting acetyl-CoA carboxylase the enzyme involved in malonyl-CoA transformation) [17].”
• AMP‐activated protein kinase – development of the energy sensor concept (2006, background): “Particularly interesting were findings that AMPK is activated by the adipokines, leptin in skeletal muscle (Minokoshi et al. 2002), and adiponectin in skeletal muscle and liver (Tomas et al.”