Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction,…

By N. Hewitt, María J Gómez Lechón, J. Houston, D. Hallifax, Hayley S. Brown, P. Maurel, J. Kenna, L. Gustavsson, C. Lohmann, Christian Skonberg and 6 more. Drug metabolism reviews (Softcover ed.), 2007

748 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/7e0586d91bab59654a9c399f7dfc6d67092d086a

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Citations in the corpus

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting (2016, background): “The complex microarchitecture and cellular interactions in liver are thought to be essential to long-term hepatocyte functional maintenance as supported by many reports on the loss of liver-specific functions from hepatocytes taken out from the liver (5, 6).”
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “In 2007, a review on the ‘‘current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies’’ was published (Hewitt et al. 2007).”
Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH) (2008, background): “For instance, the in vitro tests are planned to be complemented by means of (Q)SARs focussing on the blood-testis barrier as well as the bloodplacental barrier (Hewitt et al. 2007b).”