Exon-intron circular RNAs regulate transcription in the nucleus

By Zhaoyong Li, Chuan Huang, Chun Bao, Liang Chen, Mei Lin, Xiaolin Wang, Guolin Zhong, Bin Yu, Wanchen Hu, Limin Dai and 8 more. Nature Structural &Molecular Biology, 2015

2,644 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fafbcf2d581b4f1e76b50b774c5b214cacd5c077

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Citations in the corpus

Linking Long Noncoding RNA Localization and Function. (2016, background): “Intron-containing circular RNAs [63,64] and intron-derived sno-lncRNAs [20] are retained in the nucleus, indicating that intronic sequences may serve as ribonucleic nuclear retention elements (RNREs) that lead to lncRNA nuclear localization.”
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs (2016, positive): “For example, some cassette exons are more favorably included in circRNAs than in linear mRNAs (Zhang et al. 2014), and some introns are retained in circRNAs (Salzman et al. 2013; Zhang et al. 2014; Li et al. 2015) through alternative splicing.”
Circular RNAs: analysis, expression and potential functions (2016, background): “Thus, the function (Li et al., 2015; Memczak et al., 2013) and biogenesis (Ashwal-Fluss et al., 2014; Barrett et al., 2015; Kramer et al., 2015; Liang and Wilusz, 2014; Starke et al., 2015) of circRNAs is often studied using easily manipulable circRNA overexpression plasmids.”
Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “EIcircRNAs are able to enhance transcription of their parental (coding) genes by interacting with RNAPII in an interaction that requires the U1 small nuclear RNA (snRNA) [74].”
Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses (2016, background): “While most of the circular RNAs reported so far have been exonic circular RNAs, a class of intron-containing exonic circRNAs (EIciRNAs) are found predominantly in the nucleus,(13) where they promote transcription of their parental genes.(14) However, the functions of circular RNAs are largely unknow”
Regulation of circRNA biogenesis (2015, background): “4B).(12,20,39) Interestingly, the level of internal intron retention within a circRNA can be very different when Figure 3.”
Circular RNAs: Promising Biomarkers for Human Diseases (2018, background): “Based on the containing components of exons and introns from the parental genes, circRNAs can be divided into three categories: exonic circRNAs (ecircRNA) that only contain back-spliced exons; circular intronic RNAs (ciRNA) that come from introns; and exon-intron circRNAs (EIciRNAs) which is circula”
CSCD: a database for cancer-specific circular RNAs (2017, background): “Previous work reported that most circRNAs derived from exon were identified in cytosolic (37), while those circRNAs consisting of intron or exon–intron were mainly identified in nucleus (38).”
Circular RNA: metabolism, functions and interactions with proteins (2020, background): “Additionally, scientists have identified certain introncontaining circRNAs that are retained in the nucleus and regulate their parental gene expression [44, 45].”