Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

By W. Du, Weining Yang, Yu Chen, Zhongkai Wu, F. S. Foster, Zhenguo Yang, Xiangmin Li, Burton B. Yang. European Heart Journal, 2016

693 citations recorded by the source corpus.

Subfields: Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/4060bbf6c0720eb8217b8b8a1b856d58d83b5684

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Nan Wu
2. W. Du
3. Weining Yang
4. Faryal Mehwish Awan
5. Zhenguo Yang
6. L. Fang
7. Burton B. Yang

Citations in the corpus

• Circular RNA-protein interactions: functions, mechanisms, and identification (2020, background): “Increasingly, studies are revealing that certain proteins are able to bind to different circRNAs [91, 92], whereas several circRNAs can also dynamically bind to different proteins [22, 44].”
• Circular RNA: metabolism, functions and interactions with proteins (2020, background): “CircFoxo3 overexpression induces cardiac senescence and aggravates doxorubicin-induced cardiomyopathy by retaining the anti-senescence proteins inhibitor of DNA binding 1 (ID-1) and E2F1, as well as the anti-stress proteins tyrosine kinase 2 (FAK) and HIF1α in the cytoplasm, disrupting the functions”
• Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity (2016, methodology): “circ-Foxo3 could function by binding to proteins in related signal pathways.(10,11) In the present study, we used”
• CSCD: a database for cancer-specific circular RNAs (2017, background): “For example, CircFoxo3 interacts with anti-senescent protein ID-1 and transcription factor E2F1 to increase cellular senescence (12).”