Cytokine-associated emotional and cognitive disturbances in humans.

By A. Reichenberg, R. Yirmiya, A. Schuld, T. Kraus, M. Haack, A. Morag, T. Pollmächer. Archives of General Psychiatry, 2001

1,382 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Immunology

View Paper: https://www.semanticscholar.org/paper/fa8daed94c55f561bd08eddb5f016a0a66d5740f

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Citations in the corpus

Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. (2006, background): “Several proinflammatory cytokines (eg, tumor necrosis factor ) have been linked to both vascular disease and depression,(63-65) and the same cytokines may have direct effects on cognitive status.(66) Possible genetic links between the 2 disorders have also been explored, most notably between apolipo”
Inflammation-Associated Depression: From Serotonin to Kynurenine (2010, background): “However, more recent studies on volunteers administered low doses of endotoxin acutely (Reichenberg et al 2001) or vaccinated against typhoid (Strike et al 2004; Wright et al 2005) confirmed the basic premises of the hypothesis, i.e., that inflammation can cause depressed mood in medically healthy…”
Cytokine Targets in the Brain: Impact on Neurotransmitters and Neurocircuits (2013, background): “[30–34] The third body of data that supports the association of inflammation with symptoms of depression and anxiety are studies that have used drugs that inhibit inflammatory cytokines or their signaling pathways to reduce depression and anxiety.”
Inflammatory mediators in the elderly. (2004, background): “As for cognitive parameters, a transient increase in proinflammatory cytokines following a subclinical dose of endotoxin resulted in negative effects on memory functions and depression score in young subjects (Reichenberg et al., 2001).”
Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. (2005, background): “A study that induced cytokine activation in healthy volunteers found elevated cytokine levels were associated with impaired memory (59).”
Candidate mechanisms for chemotherapy-induced cognitive changes (2007, background): “Animal and human studies that have used various methods for stimulating a cytokine response (for example, Escherichia coli endotoxin exposure) have shown an association between the deregulation of cytokines and deficits in cognitive performanc”
The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “, endotoxin [LPS] or Salmonella typhi administrations) are known to activate microglia and induce depressive symptoms; the severity of the symptoms directly correlates with high blood levels of proinflammatory cytokines (Grigoleit et al., 2011; Harrison et al., 2009; Reichenberg et al., 2001).”
The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis (2011, positive): “…showing that acute and chronic immune stimuli, which increase serum levels of inflammatory cytokines, can elicit depressive symptoms in humans (Reichenberg et al, 2001; Wright et al, 2005; Capuron et al, 2009; Eisenberger et al, 2009; DellaGioia and Hannestad, 2010), and studies showing that…”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “Indeed, a significant percentage of patients receiving IFN-alpha therapy have been shown to exhibit hypomanic and, in some cases, manic features, including marked irritability, inability to sleep, and hyperactivity (102).”
An fMRI Study of Cytokine-Induced Depressed Mood and Social Pain: The Role of Sex Differences (2009, methodology): “Furthermore, it should be emphasized that endotoxin has been shown to increase the production and secretion of several different proinflammatory cytokines, including TNF-α and IL-1 receptor antagonist (Reichenberg et al., 2001).”
So depression is an inflammatory disease, but where does the inflammation come from? (2013, positive): “depressive-like behaviors; in studies where healthy participants are given endotoxin infusions to trigger cytokines release, classical depressive symptoms em erg [7].”
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “…example, acute administration of endotoxin and typhoid vaccination to humans leads to a host of behavioral changes, including depressed mood, fatigue, and cognitive dysfunction (Reichenberg et al, 2001; Brydon et al, 2008; Harrison et al, 2009a, b; Eisenberger et al, 2010; Hannestad et al, 2011).”