Inflammatory mediators in the elderly.

By K. Krabbe, M. Pedersen, H. Bruunsgaard. Experimental Gerontology, 2004

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Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “several inflammatory mediators in older persons((173)).”
Cytokines and their relationship to the symptoms and outcome of cancer (2008, background): “Increased levels of these cytokines in the elderly have been associated with gradual cognitive decline and development of dementi”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, positive): “Such changes were described in the aged murine brain (Ye and Johnson, 1999), in the brain of senescenceaccelerated mice (Tha et al., 2000), and in human plasma (Krabbe et al., 2004).”
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation (2007, background): “NF-jB and P-Selectin Are Activated in Aged HSCs A link between aging and inflammation has been demonstrated in several vertebrate models and in humans [15], and we found evidence for the age-dependent regulation of several stress-related genes in HSCs.”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “inflammation, a common characteristic of aging, is reflected by increased systemic levels of several pro-inflammatory cytokines, such as TNF-α, IL-6, IL-1β, and CRP, even in the absence of overt disease conditions (Bruunsgaard, 2001; Krabbe et al., 2004; Vasto et al., 2007).”