The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

By Jonas Hannestad, Nicole DellaGioia, Michael Bloch. Neuropsychopharmacology, 2011

909 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/ff9d5d947b0195113ab4a330535b4811a8ccfea1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. J. Kiecolt-Glaser
2. C. Nemeroff
3. M. Kivimaki
4. Eléonore Beurel
5. H. Derry
6. Christopher P. Fagundes
7. M. Toups
8. F. Dhabhar

In Biological Psychiatry

1. J. Kiecolt-Glaser
2. C. Nemeroff
3. Eléonore Beurel
4. H. Derry
5. Christopher P. Fagundes
6. M. Toups
7. F. Dhabhar
8. Esther M. Sternberg

In Pharmacology

1. C. Nemeroff
2. M. Kivimaki

Citations in the corpus

• Inflammation and clinical response to treatment in depression: A meta-analysis. (2015, neutral): “This association between TNFα modification and response may account for the lack of significant findings in a previous meta-analysis (Hannestad et al., 2011) which did not consider differential patterns of alteration in responders vs.”
• The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “In other studies, in contrast, antidepressants such as serotonin and norepinephrine reuptake inhibitors (SNRIs) induce IL-6 and TNF production (Hannestad et al., 2011; Warner-Schmidt et al., 2011; Piletz et al., 2009).”
• Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, result): “In line with this, two metaanalyses showed that SSRI treatment, but not other types of antidepressants, reduced inflammatory levels [138,139].”
• Inflammation: depression fans the flames and feasts on the heat. (2015, background): “A meta-analysis of the effects of antidepressant medication on cytokines showed an average 50% reduction in depressive symptoms across antidepressants, but only SSRIs appeared to affect cytokine production (191).”
• So depression is an inflammatory disease, but where does the inflammation come from? (2013, neutral): “[15], while lack of response is associated with persistently elevated levels of inflammatory markers [16].”
• Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder (2015, result): “For example, the relationships between venous blood levels of IL-6, CRP and depression have been weaker in studies using self-reported instruments rather than clinical diagnosis to ascertain depression, in community-based subjects compared to clinical samples, and when participants treated with anti”