Symptomatic atherosclerosis is associated with an altered gut metagenome

By F. Karlsson, F. Fåk, I. Nookaew, V. Tremaroli, Björn Fagerberg, Dina Petranovic, Fredrik Bäckhed, Jens Nielsen. Nature Communications, 2012

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Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Collinsella was enriched in patients with symptomatic atherosclerosis, defined as stenotic atherosclerotic plaques in the carotid artery leading to cerebrovascular events, whereas Roseburia and Eubacterium were enriched in healthy controls. Further characterization of the functional capacity of the metagenomes revealed that patient gut metagenomes were enriched in genes encoding peptidoglycan synthesis and depleted in phytoene dehydrogenase; patients also had reduced serum levels of β-carotene. Our findings suggest that the gut metagenome is associated with the inflammatory status of the host and patients with symptomatic atherosclerosis harbor characteristic changes in the gut metagenome. The gut microbiota has emerged as an environmental factor that can influence the development of obesity and diabetes. Here, Karlsson et al. report compositional and functional alterations of the gut metagenome in patients with symptomatic atherosclerosis.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/fa78fbe4819f11f57f8abcdc9460b2aceded402d

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Citations in the corpus

An Extensive Evaluation of Read Trimming Effects on Illumina NGS Data Analysis (2013, positive): “Trimming has been broadly adopted in most recent NGS studies, specifically prior to genome assembly [23], transcriptome assembly [24], metagenome reconstruction [25], RNA-Seq [26,27], epigenetic studies [7] and comparative genomics [28].”
Pathophysiology of Atherosclerosis (2022, positive): “The presence of microorganisms in the atheroma plaque is well established, and some studies have shown that the abundance of certain phyla could correlate with plaque stability and overall inflammation [346,347].”
Gut Microbiota in Cardiovascular Health and Disease (2017, neutral): “the microbiome to produce proinflammatory peptidoglycans and reduced production of anti-inflammatory carotenes.(4) The”
Dietary lipids, gut microbiota and lipid metabolism (2019, positive): “Functionally, the gut microbiome of patients had increased capacity for peptidoglycan synthesis, which might contribute to the chronic inflammation in the atherosclerotic arterial walls [41].”
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance (2013, positive): “Interestingly, a higher abundance of genus Collinsella in T2DM compared with NGT and pre-DM was detected, and it has been reported that this genus shows a positive correlation with serum cholesterol, and is also enriched in patients with symptomatic atherosclerosis [31,32].”
Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke (2016, positive): “These findings on poststroke dysbiosis are consistent with recent reports describing changes in intestinal microbiota composition in stroke patients (Karlsson et al., 2012; Swidsinski et al., 2012; Yin et al., 2015).”
Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015, positive): “org) (Table S2) using methods from our MEDUSA platform (Karlsson et al., 2012; Karlsson et al., 2014).”
Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries (2020, positive): “38 40–43 These findings collectively suggest that adherence to the MedDiet has the potential to modulate the microbiome in a direction positively associated with health.”