Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

By John I. Glass, Elliot J. Lefkowitz, Jennifer S. Glass, Cheryl R. Heiner, Ellson Y. Chen, G. Cassell. Nature, 2000

1,548 citations recorded by the source corpus.

Subfields: Ecology, Mechanics of Materials, Plant Science

View Paper: https://www.semanticscholar.org/paper/fa3f1884e77f302a88c22d6b578aebe3ddea448c

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In Ecology

1. M. Parsek
2. D. Davies
3. M. Givskov
4. Bernd H. A. Rehm
5. Kim Lewis
6. J. López-Ribot
7. G. Ramage
8. M. Hentzer

In Plant Science

1. Bernd H. A. Rehm
2. Kim Lewis

Citations in the corpus

• Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa (2006, background): “For example, the opportunistic pathogen Pseudomonas aeruginosa causes persistent infections in the lungs of cystic fibrosis patients that are frequently associated with the emergence of antibiotic-resistant subpopulations of bacteria (57).”
• Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor (2008, background): “Cells of the opportunistic pathogen Pseudomonas aeruginosa form biofilms in a variety of situations including on indwelling medical devices as well as in the lungs of cystic fibrosis patients (Costerton et al., 1999; 2003; Singh et al., 2000; Hoiby, 2002; Yahr and Greenberg, 2004).”
• Gene expression in Pseudomonas aeruginosa biofilms (2001, neutral): “aeruginosa colonizes the cystic fibrosis lung it cannot be eradicated by even the most aggressive antibiotic therap”
• A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria (2010, background): “aeruginosa (Sibley et al., 2006; Singh et al., 2000).”
• Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix (2009, background): “environmental bacterium can form biofilms on a variety of surfaces such as the mucus plugs of the CF lung, contaminated catheters, and contact lenses [8,9].”
• Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. (2002, background): “Recent 7 Department of Pulmonary Biology chemical studies revealed that CF sputum contains two University of North Carolina QS signaling molecules, N-butyryl-L-homoserine lacChapel Hill, North Carolina 27599 tone (C4-HSL) and N-(3-oxododecanoyl)-L-homoserine 8 Department of Biology lactone (3O-C12-H”
• Anti-virulence strategies to combat bacteria-mediated disease (2010, background): “Biofilms have been linked to a growing list of medically relevant pathogens including Pseudomonas aeruginosa , which causes several types of nosocomial infection and cystic fibrosi”
• The application of biofilm science to the study and control of chronic bacterial infections. (2003, background): “aeruginosa in the CF lung do indeed grow in the biofilm phenotype (9).”
• Multi-species biofilms: living with friendly neighbors. (2012, background): “Quorum sensing has been shown to play an important role in the development of biofilms (Davies et al., 1998; Singh et al., 2000; Zhu et al., 2002; Riedel et al., 2009; Bjarnsholt et al., 2010), although its impact, namely induction vs.”
• Lung Infections Associated with Cystic Fibrosis (2002, background): “based principally on electron microscopic evidence (168, 298) that has yet to be adequately coupled to the major molecular”
• The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections (2012, neutral): “extracellular polysaccharide alginate (a condition CF.[49] P.”
• Inter-kingdom signalling: communication between bacteria and their hosts (2008, background): “aeruginosa , in which AHLs are required to regulate colonization and persistence during infectio”