Gene expression in Pseudomonas aeruginosa biofilms

By M. Whiteley, M. Bangera, Roger E Bumgarner, M. Parsek, Gail M. Teitzel, S. Lory, E. P. Greenberg. Nature, 2001

1,196 citations recorded by the source corpus.

Subfields: Genetics, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/085b899835655bd7493b7f0f193e0c7c449ef91a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. T. Bjarnsholt
2. Brian K. Hammer
3. B. Bassler
4. Sivan Elias
5. E. Banin
6. D. Davies
7. A. Price-Whelan
8. Ashley Petersen

In Microbiology

1. P. Stewart
2. J. Kaplan
3. A. Price-Whelan
4. Ashley Petersen
5. Lars E. P. Dietrich
6. D. Newman
7. Robert E. W. Hancock
8. M. Whiteley

In Molecular Biology

1. T. Bjarnsholt
2. J. Kaplan
3. P. Stewart
4. B. Bassler
5. M. Givskov
6. M. Parsek
7. Søren Molin
8. P. Stoodley

Citations in the corpus

• Quorum sensing controls biofilm formation in Vibrio cholerae (2003, background): “Even within single species biofilms, differential spatial and temporal gene expression occurs (Whiteley et al., 2001).”
• Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin (2003, positive): “It is possible that the relatively retarded penetration of tobramycin contributes to the protection of the biofilm by allowing more time for bacteria to implement adaptive stress responses (32).”
• Pseudomonas genomes: diverse and adaptable. (2011, background): “Numerous studies have exploited the development of microarrays, designed based on genome sequence data, in order to study gene expression in response to different environments, such as during biofilm growth (Whiteley et al., 2001) or exposure to oxidative stress (Salunkhe et al., 2005).”
• Pseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm (2002, result): “Our finding of increased glyceraldehyde-3-phosphate dehydrogenase levels is in contrast to a recent report by Whiteley and colleagues, where the gene for this enzyme was found to be downregulated fourfold in 5-day-old P. aeruginosa biofilm cells ( 52 ).”
• Multi-species biofilms: living with friendly neighbors. (2012, background): “…susceptibility of multi-species vs. mono-species biofilms, and in most cases, the mixed-species biofilm was significantly more resistant to antimicrobial treatment or disinfection (Whiteley et al., 2001; Leriche et al., 2003; Al-Bakri et al., 2005; Burmolle et al., 2006; Kara et al., 2006).”
• Resistance of bacterial biofilms to disinfectants: a review (2011, background): “(Prigent-Combaret et al. 1999; Whiteley et al. 2001; Sauer 2003; Vilain et al. 2004; Shemesh et al. 2007).”
• A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance (2003, methodology): “RNA was prepared from biofilm-grown and planktonically grown cells from a continuous culture syste”
• The role of bacterial biofilms in chronic infections (2013, background): “showed that the transcriptomes of biofilm-producing bacteria are similar to those of planktonic growing bacteria, and any differences were mainly related to antibiotic tolerance (334).”