Microglia as neuroprotective, immunocompetent cells of the CNS

By Wolfgang Streit. Glia, 2002

945 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/fa10c46f08bb7f086a7db8e5504e5b95c2aa89be

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Clifford J. Woolf
2. M. Block
3. Jau-Shyong Hong
4. Luis Ulloa
5. J. Scholz
6. W. Jonge
7. Arne May
8. R. Ji

In Neurology

1. M. Block
2. Jau-Shyong Hong
3. J. Scholz
4. Luis Ulloa
5. W. Jonge
6. Clifford J. Woolf
7. G. Moalem-Taylor
8. P. Austin

In Physiology

1. Clifford J. Woolf
2. J. Scholz
3. M. Block
4. Jau-Shyong Hong
5. Luis Ulloa
6. W. Jonge
7. Arne May
8. R. Ji

Citations in the corpus

• Microglia-mediated neurotoxicity: uncovering the molecular mechanisms (2007, background): “In their activated state, they can serve diverse beneficial functions essential to neuron surviva”
• Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function (2009, background): “In the brain, however, Cox2 is constitutively expressed by neurons (212, 512), participates in modulating synaptic plasticity (53, 464), and conditionally can either inhibit or promote cell death (74, 85, 237, 322, 451).”
• The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation (2007, background): “Activated microglia can be of crucial importance in CNS pathology via liberation of free radicals as well as cytokines and toxic factors (Streit, 2002).”
• Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, neutral): “While these glial responses are benefi cial to neurons, the continuous or repeated activation of astrocytes and microglia under conditions of chronic infl ammatory stresses can lead to the increased production of ROS/RNS and other neurotoxic mediators, which can lead to severe neuronal damage (Banat”
• Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia (2013, background): “Microglial cells are major effector cells of innate immunity in the central nervous system (CNS) (Streit, 2002).”
• Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain (2007, background): “However, there is a growing line of evidence suggesting a neuroprotective role for microglia in CNS pathologies (Streit, 2002; Neumann et al., 2006).”
• The neuropathic pain triad: neurons, immune cells and glia (2007, background): “Macrophages, which are derived from circulating monocytes, and microglia, the resident mononuclear phagocytes of the CNS, share numerous similarities in their immunological and functional propertie”
• Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “Under physiological conditions, microglia exhibit a deactivated phenotype that is associated with the production of anti-inflammatory and neurotrophic factors (Streit, 2002).”