Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

By Joseph W. Thornton. Proceedings of the National Academy of Sciences of the United States of America, 2001

645 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Genetics

View Paper: https://www.semanticscholar.org/paper/f9dc54a0ffc71a433e6a0a7866a1e9c5df4cf79f

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Citations in the corpus

Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. (2005, background): “Thus, there is no indication that these mERs and mPRs arose from a common ancestor, unlike members of the nuclear steroid receptor superfamily (51).”
Similarities, Differences, and Unknowns in Biology and Management of Three Parasitic Lampreys of North America (2010, background): “2008), and the role of estradiol in reproduction is further supported by the recent cloning of an estrogen-like receptor in sea lamprey (Thornton 2001).”
The complete nuclear estrogen receptor family in the rainbow trout: Discovery of the novel ERα2 and both ERβ isoforms (2007, background): “Nuclear ERs belong to a well-established superfamily of steroid hormone receptors that include androgen, progestin, and mineralocorticoid receptors (Laudet et al., 1992; Thornton, 2001).”
Alligator Tales: New Lessons about Environmental Contaminants from a Sentinel Species (2008, background): “The ancestral condition for the jawed vertebrates (Gnathostomata) appears to have been the presence of two forms of ER, corresponding to ERα and ERß; two forms of thyroid receptor; one AR; and one progestin receptor (Thornton 2001).”
Fish Gonadogenesis. Part II: Molecular Biology and Genomics of Sex Differentiation (2008, background): “The evolution of AR as well as other nuclear receptors such as the progesterone receptor (PR) from an ancestral ER has been determined (Thornton, 2001).”
Mechanistic approaches to the study of evolution: the functional synthesis (2007, background): “Similarly, Thornton's group has found that several other hormone–receptor pairs also evolved when new molecules co-opted old molecules that once had different function”
Turning a hobby into a job: How duplicated genes find new functions (2008, background): “Because progesterone and testosterone are both intermediates in the pathway of oestrogen synthesis, it is reasonable to argue that these intermediates were later co-opted as hormone”
Sources of estrogen and their importance. (2003, background): “Consistent with this, phylogenetic analysis of steroid receptors in lower vertebrates indicates that the first steroid receptor was an estrogen receptor, followed by a progesterone receptor [31].”
Constraints Evolve: Context Dependency of Gene Effects Allows Evolution of Pleiotropy (2015, background): “…relationships have arisen by recruitment of an intermediate product of ligand production, becoming a ligand to a duplicated estrogen receptor (such as progesterone, an intermediate product of estrogen production and its receptor), resulting in androgen and progestin receptors (Thornton 2001).”
Endocrine-disrupting chemicals: an Endocrine Society scientific statement. (2009, background): “There is no endocrine system that is immune to these substances, because of the shared properties of the chemicals and the similarities of the receptors (13) and enzymes involved in the synthesis, release, and degradation of hormones (Fig 1).”