Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

By P. Thomas, Y. Pang, E. Filardo, Jing Dong. Endocrinology, 2005

1,434 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/0b71d9fb2efbba553debf920602929711e26f06e

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In Genetics

1. J. Mclachlan
2. J. Sullivan

In Molecular Biology

1. J. Gutkind
2. J. Sullivan
3. R. Dorsam

Citations in the corpus

• Estrogen synthesis and signaling pathways during ageing: from periphery to brain (2013, background): “GPR30, an orphan G protein coupled receptor, has been identified by several independent groups as membrane estrogen receptor which can trigger rapid estrogen non-genomic signaling independent of ERα and ERβ [53].”
• Possible roles of sex steroids in the control of reproduction in bivalve molluscs (2007, background): “Finally, a novel family of G-protein receptors which bind to sex steroids has recently been discovered in vertebrates (Revankar et al., 2005; Thomas et al., 2006, 2005 ) and orthologues in the invertebrates might explain many of the effects of steroids in these animals.”
• G-protein-coupled receptors and cancer (2007, background): “The activation of GPR30 stimulates cyclic AMP (cAMP) and phosphatidylinositol trisphosphate (PIP 3 ) accumulation concomitant with increased phosphatidylinositol bisphosphate (PIP 2 ) hydrolysis, increases intracellular calcium levels by stimulating Gα s , Gα i and Gα q”
• Virtual and biomolecular screening converge on a selective agonist for GPR30 (2006, methodology): “To accomplish the biomolecular screening, we used a fluorescently labeled estrogen derivative (an Alexa633 conjugate of 17a-[4aminomethyl-phenylethynyl]-estra-1,3,5(10)-triene-3,17b-diol (5), E2Alexa633) that we have recently developed and shown to bind GPR30 as well as ERa and ERb (ref.”
• The complete nuclear estrogen receptor family in the rainbow trout: Discovery of the novel ERα2 and both ERβ isoforms (2007, background): “Recent evidence demonstrates that the ERs involved in the nongenomic pathway belong to the G protein-coupled receptor family, which is distinct and different from nuclear ERs (Revankar et al., 2005; Thomas et al., 2005).”
• Integration of the extranuclear and nuclear actions of estrogen. (2005, background): “(33) identified GPR30 as a low-capacity receptor for E2, one capable of supporting a modest generation of cAMP.”
• In vitro molecular mechanisms of bisphenol A action. (2007, background): “A candidate G-protein coupled membrane estrogen receptor (GPR30) that binds estradiol and the endocrine disruptor ortho,para-dichlorodiphenyldichloroethylene (o,p′-DDE) with relatively low affinities has been described [71].”
• The G protein-coupled estrogen receptor GPER in health and disease (2011, background): “Two studies published in 2005 described binding of 17β-estradiol to GPR30 in GPR30-transfected COS7 and HEK293 cells, as well as various breast cancer cell lines”