Gene silencing as an adaptive defence against viruses

By P. Waterhouse, Ming-Bo Wang, T. Lough. Nature, 2001

1,068 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f91d5ce4e6b592bcb30bdc9a32ebe80cc3b8ccd9

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Citations in the corpus

Lentivirus-delivered stable gene silencing by RNAi in primary cells. (2003, background): “RNAi provides plants with effective antiviral defenses (for review, see Waterhouse et al. 2001).”
Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. (2002, background): “Experiments in plants (41,42) and nematodes (1,43) have suggested the existence of a system whereby certain siRNA genes are involved in the heritability of RNAi-induced phenotypes.”
Generation of transgenic potato plants highly resistant to potato virus Y (PVY) through RNA silencing (2004, background): “In all cells where PTGS is active, these small sequencespecific sense and antisense RNAs of 21-25 nts become detectable Hamilton and Baulcombe 1999; Waterhouse et al. 2001a .”
Genetic and Functional Diversification of Small RNA Pathways in Plants (2004, background): “In plants and insects, post-transcriptional RNAi serves as an adaptive antiviral defense response (Waterhouse et al. 2001; Li et al. 2002). miRNAs are fully competent to guide nucleolytic function of RISC, provided that a target sequence with sufficient complementarity is available (Hutvágner and…”
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. (2002, background): “RNA interference (RNAi) is the process of sequencespecific posttranscriptional gene silencing (PTGS) in a variety of organisms, initiated by the introduction of double-stranded (ds) RNA that is homologous in sequence to the silenced gene (Fire et al. 1998; for review, see Cogoni andMacino 2000; Vanc”
Construct design for efficient, effective and high-throughput gene silencing in plants. (2001, background): “Similar 21±25 nt RNAs have also been found associated with PTGS in plants (Hamilton and Baulcombe, 1999; Waterhouse et al., 2001).”
Genetic diversity and evolution of hepatitis C virus--15 years on. (2004, background): “Mammalian cells may additionally control RNA virus infections through the actions of the mammalian homologues of Dicer and the siRNAarmed RNA-induced silencing complex (Waterhouse et al., 2001; Gitlin & Andino, 2003).”
Neoliberalism on the molecular scale. Economic and genetic reductionism in biotechnology battles (2003, background): “These multiple phenotypic expressions, or ‘‘pleiotropic’’ effects, may be related to alterations in plant metabolic pathways and, possibly, to the ‘‘silencing’’ of preexisting genes that can be caused by the insertion of genetic constructs (Bruening, 1998; Brown, 2000; Al-Kaff et al., 2000; Waterhou”
Mechanisms of gene silencing by double-stranded RNA (2004, background): “RNA silencing mechanisms were first recognized as antiviral mechanisms that protect organisms from RNA viruse”
Applications and advantages of virus-induced gene silencing for gene function studies in plants. (2004, neutral): “technology (Waterhouse et al., 2001).”
A biochemical framework for RNA silencing in plants. (2003, background): “…eukaryotes, quelling in fungi, and posttranscriptional gene silencing (PTGS) in plants are examples of a broad family of phenomena collectively called RNA silencing (Kooter et al. 1999; Li and Ding 2001; Matzke et al. 2001; Vaucheret et al. 2001; Waterhouse et al. 2001; Hannon 2002; Plasterk 2002).”