A role for lateral hypothalamic orexin neurons in reward seeking

By G. Harris, M. Wimmer, Gary S. Aston-Jones. Nature, 2005

1,311 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/f90c2e82596901ec8e31ab58e9b0ff3a1f11b21d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Endocrine and Autonomic Systems

In Experimental and Cognitive Psychology

Citations in the corpus

Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. (2008, background): “, 2005; Koob and Le Moal, 2005; Mogenson and Yang, 1991; Wise, 1997; Yeomans, 1995), and many neurotransmitters have been studied in these and related brain regions (Harris et al., 2005; Kalivas, 2004; Leibowitz and Hoebel, 2004; Schoffelmeer et al., 2001; Stein and Belluzzi, 1979).”
The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. (2010, neutral): “…and satiety (Baldo and Kelley, 2007; Baldo et al., 2004; Berthoud and Morrison, 2008; Carr, 2007; Finlayson et al., 2007; Fulton et al., 2006; Harris et al., 2005; Harris and Aston-Jones, 2006; Kelley et al., 2005b; Mela, 2006; Myers, 2008; Palmiter, 2007; Robertson et al., 2008; Scammell…”
A role for brain stress systems in addiction. (2008, neutral): “Orexin neurons in the lateral hypothalamus are activated by cues associated with rewards, such as food or drugs, and exogenous stimulation of lateral hypothalamic orexin neurons reinstates extinguished drug-seeking behavior in rodents (Harris et al., 2005).”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, neutral): “For example, orexin afferents from the hypothalamus (Fadel et al, 2002) mediate an importance influence on reward behaviors (Harris et al, 2005) and synaptic plasticity (Borgland et al, 2006) presumably by excitatory actions on DA cells (Korotkova et al, 2003).”
‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, background): “For example, hypothalamic orexin–hypocretin neurons send projections to modulate the nucleus accumbens in ways that might allow hunger states to enhance food reward [165], and even interact with other rewards such as drugs [160].”
Involvement of the endocannabinoid system in drug addiction. (2006, background): “Interestingly, hypothalamic orexins, in addition to endocannabinoids, are directly involved in the rewarding effects of drugs of abuse and the relapse to drug-seeking behaviour [ 75 ].”
Sleep State Switching (2010, background): “, 1999) and may play an important role inmotivating foraging behaviors in hungry animals as well as in reward and drug seeking behaviors (Harris et al., 2005; Yamanaka et al., 2003).”
The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “Neural mechanisms for that integration involve inputs from other brain systems, such as hypothalamic orexin and other signals about physiological homeostasis, that impact on mesolimbic function (Baldo et al. 2003; Harris et al. 2005; Kelley et al. 2005a; Narita et al. 2006; Zheng et al. 2003).”
Synaptic plasticity and addiction (2007, background): “, whereas an orexin receptor 1 (OXR1) antagonist blocks acquisition of conditioned place preference when delivered locally to the VT”