Sleep State Switching
By Clifford B. Saper, P. Fuller, N. Pedersen, Jun Lu, T. Scammell. Neuron, 2010
1,282 citations recorded by the source corpus.
We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but these changes in behavioral state require specific switching mechanisms in the brain that allow well-defined state transitions. In this review, we examine the basic circuitry underlying the regulation of sleep and wakefulness, and discuss a theoretical framework wherein the interactions between reciprocal neuronal circuits enable relatively rapid and complete state transitions. We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching, and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy.
Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology
View Paper: https://www.semanticscholar.org/paper/274b4663466f5349a696a128d6820eeb21ec9dbb
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
- David A. McCormick
- Matthew McGinley
- Martin A. Vinck
- R. Batista-Brito
- Andreas S. Tolias
- V. Jayaraman
- Gerald M. Rubin
- Edward Zagha
In Endocrine and Autonomic Systems
Citations in the corpus
- A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection (2020, background): “This simple motif resembles the classic ‘flip-flop’ circuit model of brain state regulation thought to underlie sleep-wake control in mammals (reviewed in (Saper et al., 2010)).”
- Neuromodulation of brain states. (2012, neutral): “This has led to the proposal of an elegant flip-flop circuit for sleep-wake switches based on the mutual inhibition between the VLPO and ascending arousal system (Saper et al., 2010).”
- Waking State: Rapid Variations Modulate Neural and Behavioral Responses (2015, positive): “A wide variety of neuromodulatory pathways have been implicated in the neural control of cortical responsiveness in a state dependentmanner (reviewed in Saper et al., 2010; Steriade and McCarley, 2005).”