CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer

By Matthew C. P. Smith, K. Luker, J. Garbow, Julie L. Prior, Erin N. Jackson, D. Piwnica-Worms, G. Luker. Cancer Research, 2004

733 citations recorded by the source corpus.

How researchers see this paper

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Beyond tumorigenesis: cancer stem cells in metastasis (2007, background): “In fact, blocking the homing factor CXCR4 has been shown to effectively prevent both primary tumor formation as well as metastasis in animal models [ 97 ].”
Cancer to bone: a fatal attraction (2011, unknown): “CXCL12 is expressed at high levels by osteoblasts and bone marrow stromal cells, and expression of its receptor, CXCR4, on cancer cells has an important role in tumour cell homing to bon”
Investigating the optimal size of anticancer nanomedicine (2014, methodology): “into BALB/c mice on day 0 to establish an experimental metastatic tumor model (39).”
The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. (2007, background): “SDF-1 has been shown to promote directly tumor vasculature development [59] or to support only the growth and metastasis of CXCR4+ tumors [63], underscoring distinct SDF-1 functions in different cancer types.”
The role of CXC chemokines and their receptors in cancer. (2008, background): “[144] M.”
Cancer stem cells: an old idea--a paradigm shift. (2006, background): “For example, homing receptors found on normal hematopoietic stem cells, such as the cytokine receptor CXCR4, have been shown to play an important role in promoting metastases in a variety of tumors, including human breast and prostate carcinomas (41, 42).”