Making heads or tails of phospholipids in mitochondria
By C. Osman, D. Voelker, T. Langer. Journal of Cell Biology, 2011
599 citations recorded by the source corpus.
Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis.
Subfields: Clinical Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f87ea08035b4d98bd7d3cb5315358f2a4020ffdc
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In Clinical Biochemistry
In Molecular Biology
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Citations in the corpus
- Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation (2013, background): “Its structure is unique because it consists of two diacylated phosphatidyl groups joined by a glycerol bridge (Osman et al., 2011).”
- Mitochondria: In Sickness and in Health (2012, background): “The biogenesis of IM domains is an active process highly dependent on the mitochondrial-specific anionic lipids, phosphotidylethanolamine and cardiolipin, whose transport and levels within mitochondria are tightly controlled by a surprisingly complex set of factors (Osman et al., 2011).”
- Lipids of mitochondria. (2013, background): “Some aspects of the physiological relevance of mitochondrial lipids will be addressed, but for more details describing these aspects the reader is referred to recent reviews [9,12,13].”
- Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. (2014, background): “PG is biosynthesized in themitochondria [70], or by the transphosphatidylation activity of the plasmamembrane phospholipase D2 (PLD2) in the presence of exogenous glycerol [71].”