Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

By P. Puigserver, B. Spiegelman. Endocrine reviews, 2003

2,143 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/f86abd01f3fef9c51158ac23b3e8659fedb9d418

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In Molecular Biology

1. B. Spiegelman
2. R. Scarpulla
3. Matthias Mann
4. Jesper V. Olsen
5. Christoph Handschin
6. Jiandie D. Lin
7. E. Rosen
8. Jacek R. Wisniewski

In Physiology

1. B. Spiegelman
2. R. Scarpulla
3. Christoph Handschin
4. Jiandie D. Lin
5. E. Rosen
6. P. Seale
7. D. Kelly
8. Wenli Yang

Citations in the corpus

• Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. (2003, background): “While none of these factors have lism and coactivated by PGC-1 , a regulator of mitochondrial biogenesis (Puigserver and Spiegelman, 2003).previously been shown to exhibit expression patterns correlated with mitochondrial genes, several have pre- A number of other transcription factors, including…”
• Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes (2009, background): “The transcriptional coactivator PPARGC1A coordinates gene expression that stimulates mitochondrial oxidative metabolism in multiple tissues (77).”
• Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. (2006, background): “…receptor-γ (PPARγ) coactivator-1α (PGC-1α) is an integrator of the molecular regulatory circuit involved in the transcriptional control of cellular energy metabolism, including mitochondrial biogenesis, hepatic gluconeogenesis, and fatty acid β-oxidation (Puigserver and Spiegelman, 2003).”
• Cell and Molecular Biology (2009, background): “These phenotypic changes were associated with increased expression of PGC-1a, a key regulator of mitochondrial biogenesis (Puigserver and Spiegelman, 2003; Wu et al., 1999) and an activator of the mitochondrial fatty acid oxidation pathway (Vega et al.”
• What We Talk About When We Talk About Fat (2014, positive): “PGC-1a exerts its actions on mitochondria and oxidation via interactions with transcription factors like ERRa, Nrf-2, PPARa, and PPARg (Giguère, 2008; Puigserver and Spiegelman, 2003); the transcription factor partners of PGC-1a that control thermogenesis are still unknown.”
• PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “As previously mentioned, PGC-1α contributes to the regulation of lipid and carbohydrate metabolism through the βoxidation of fatty acids and hepatic gluconeogenesis, respectively [48].”