Mechanisms of viral membrane fusion and its inhibition.

By D. Eckert, P. S. Kim. Annual Review of Biochemistry, 2001

1,314 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging, Virology

View Paper: https://www.semanticscholar.org/paper/f8567f81314b8c6238d3e6750cb483e1704fe871

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In Immunology

1. Dimiter S. Dimitrov
2. D. C. Chan
3. Fang Li

In Radiology, Nuclear Medicine and Imaging

1. Dimiter S. Dimitrov
2. D. C. Chan
3. Fang Li

In Virology

1. Dimiter S. Dimitrov
2. D. C. Chan
3. Fang Li

Citations in the corpus

• Mitochondrial fusion and fission in mammals. (2006, background): “Studies on virus-mediated and SNAREmediated membrane fusion have highlighted some common themes in the fusion of biological membranes (Bonifacino & Glick 2004, Eckert & Kim 2001).”
• HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes (2009, neutral): “C52L and other gp41-derived peptides inhibit fusion by binding to intermediate gp41 conformations formed upon Env interactions with CD4 and CR and preventing the formation of the final 6-helix bundle structure (reviewed in Eckert and Kim, 2001 ).”
• Structure, Function, and Evolution of Coronavirus Spike Proteins (2016, background): “Among these proteins, the hemagglutinin glycoprotein (HA) of the influenza virus is arguably the best studied (104, 105).”
• Virus entry: molecular mechanisms and biomedical applications (2004, background): “Rhabdoviridae ssRNA Enveloped Rabies virus Endocytosis, acetylcholine Rabies (11-15) (45-100) receptor, neural cell adhesion molecule”
• Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme (2008, background): “The gp41 ectodomain forms a trimer-of-hairpins in its final form with a prominent six-helix bundle in which three C-HR (HR2) helices pack, in an antiparallel fashion, in the grooves created by a central triple helical coiled-coil composed of three N-HR (HR1) regions (Eckert and Kim, 2001; Gallo et a”
• The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex (2003, background): “Membrane fusion mediated by class I fusion proteins is accompanied by dramatic structural rearrangements within the viral polypeptide complexes (19).”
• Evolutionary velocity with protein language models (2021, neutral): “We next analyzed the evolution of influenza A hemagglutinin (HA), a more variable protein on the viral surface responsible for viralhost membrane fusion (Eckert and Kim, 2001; Harrison, 2008).”
• Protonation‐mediated structural flexibility in the F conjugation regulatory protein, TraM (2006, background): “Particularly interesting is the fact that many of these envelop proteins also undergo a pH-dependent conformational reorganiza- tion of the helical bundle upon exposure to the low-pH environment of the endosome (for a review, see Eckert and Kim, 2001).”