The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex

By B. Bosch, R. van der Zee, C. D. de Haan, P. Rottier. Journal of Virology, 2003

1,406 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/88ac127a34e5fbfd9811df4cfd7dd039b3a677d1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Animal Science and Zoology

1. P. Masters
2. D. Veesler
3. A. Walls
4. S. Weiss
5. M. A. Tortorici
6. S. Perlman
7. Gary R. Whittaker
8. J. Millet

In Infectious Diseases

1. P. Masters
2. D. Veesler
3. A. Walls
4. M. A. Tortorici
5. S. Weiss
6. J. Millet
7. Gary R. Whittaker
8. S. Perlman

Citations in the corpus

• Virus entry: molecular mechanisms and biomedical applications (2004, background): “Rhabdoviridae ssRNA Enveloped Rabies virus Endocytosis, acetylcholine Rabies (11-15) (45-100) receptor, neural cell adhesion molecule”
• A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry (2010, background): “Like other class I viral fusion proteins, the HCoV spikes require proteolytic priming to be activated (7).”
• Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event (2005, background): “The S protein, which consists of 1,361 aa, plays an important role in the attachment of the virus to cell surface receptors and induces the fusion of the viral and cellular membranes (5, 55).”
• Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods (2020, neutral): “CoVs contain at least four structural proteins: Spike (S) protein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein 10 .”
• Coronaviruses: An Overview of Their Replication and Pathogenesis (2015, background): “Cleavage at S2′ exposes a fusion peptide that inserts into the membrane, which is followed by joining of two heptad repeats in S2 forming an antiparallel six-helix bundle [ 6 ].”
• Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus (2005, background): “Recent studies of the HR domains provide further evidence confirming that the coronavirus spike is indeed a class I fusion protein (23).”
• Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag (2020, background): “The S1 subunit helps in receptor binding and the S2 subunit facilitates membrane fusion (Bosch et al., 2003; Li, 2016).”