Virus entry: molecular mechanisms and biomedical applications
By Dimiter S. Dimitrov. Nature Reviews Microbiology, 2004
624 citations recorded by the source corpus.
Viruses have evolved to enter cells from all three domains of life — Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Advances in our understanding of how viral entry proteins interact with their host-cell receptors and undergo conformational changes that lead to entry offer unprecedented opportunities for the development of novel therapeutics and vaccines.
Subfields: Epidemiology, Genetics, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/ab1da217df49a2b631ddea864863c39551c7bf05
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Citations in the corpus
- Avoiding the void: cell-to-cell spread of human viruses (2008, background): “The interactions between many viral glycoproteins and attachment receptors are highly specific, such as the HIV-1–CD4 interaction, whereas other interactions are less specific, such as the interaction between viral glycoproteins and cell-surface heparan sulphate proteoglycan”
- Silver Nanoparticles as Potential Antiviral Agents (2011, background): “Interfering with these recognition events, and thereby blocking viral entry into the cells, is one of the most promising strategies being pursued in the development of new antiviral drugs and preventive topical microbicides [14,15,16].”
- Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “There are two distinct major pathways of viral entry into eukaryotic cells [1378, 1379, 1380]: (i) the vesicular pathway, and (ii) non-vesicular pathway.”