A distinct "side population" of cells with high drug efflux capacity in human tumor cells.

By C. Hirschmann-Jax, A. Foster, Gerald Wulf, G. Wulf, J. Nuchtern, T. Jax, U. Gobel, Margaret A. Goodell, M. Brenner. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,350 citations recorded by the source corpus.

Subfields: Epidemiology, Neurology, Oncology

View Paper: https://www.semanticscholar.org/paper/f851a787d704ec083e9ef0377f886b49a7230e2f

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Citations in the corpus

• Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “described the existence of SP cells in neuroblastoma cell lines as well as in breast and lung cancers [51].”
• Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. (2007, result): “As observed by other investigators ( 9 , 10), we also found both in vitro and in vivo evidence for the SP to regenerate a population of cells composed of both SP and non-SP, resembling the original unsorted population, thus showing repopulating capacities similar to stem cells.”
• Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “In support of this concept, treatment of neuroblastoma cell lines with mitoxantrone actually increases the side population, suggesting that stemlike cancer cells are relatively resistant to this chemotherapeutic agent and accumulate as more differentiated cells are killed (51).”
• CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis (2006, background): “These side population cells have been identified in breast cancer cell lines of luminal type, and these cells overexpress transporter genes ABCG2 (ATP-binding cassette, subfamily G, member 2) and ABCA3 (ATP-binding cassette, subfamily A, member 3) [46].”
• Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, methodology): “There are several ways to enrich for tumour-initiating cells: using cell sorting techniques to select for combinations of cell-surface markers, sorting to select for a subpopulation of cells that efflux dye”
• Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy (2008, background): “. In analogy to hematopoietic stem cells, solid tumor CSC have been proposed to exhibit high level expression of multidrug transporter family genes, such as ABCG2 and ABCB5, likely resulting in more efficient efflux of chemotherapeutic drugs”
• PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells (2009, background): “These cells are pluripotent and have greater growth capacity and resistance to cytotoxic drugs as compared to non-SP cells (Hirschmann-Jax et al., 2004).”
• Models, mechanisms and clinical evidence for cancer dormancy (2007, background): “In neuroblastoma, cancer stem cells expressing ABCA3 are mitoxantrone resistan”