Chromatin Compaction by a Polycomb Group Protein Complex

By N. Francis, Robert E. Kingston, C. Woodcock. Science, 2004

892 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/41f8d5c0c262ce6bdf1efa990b0ef10bc1d70b23

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “, 2001) as well as by compacting nucleosome arrays (Francis et al., 2004).”
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. (2006, background): “, 2005), while Lys27 methylation negatively regulates transcription by promoting a compact chromatin structure (Francis et al., 2004; Ringrose et al., 2004).”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “Arrays of nucleosome cores can be condensed by binding of linker histone near the nucleosome dyad axis (Zhou et al. 1998), binding of corepressor complexes (Fan et al. 2004; Francis et al. 2004; Sekiya and Zaret 2007), and folding of nucleosomes into higherorder structures (Schwarz and Hansen 1994).”
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells (2009, background): “This histone mark then provides a platform to recruit PRC1 (Cao et al., 2002; Min et al., 2003), which aids in PcG-mediated repression either by chromatin compaction or by interfering with the transcription machinery (Francis et al., 2004; Ringrose and Paro, 2004; Sarma et al., 2008).”
Mechanisms of Polycomb gene silencing: knowns and unknowns (2009, background): “PRC1, either in the intact form isolated from cells or in the reconstituted form, has been shown to repress transcription in vitro , inhibit ATP-dependent chromatin remodelling and compact nucleosome arrays (observed by electron microscopy”
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put (2013, background): “, 2005), as well as a nonenzymatic function, compaction of polynucleosomes (Francis et al., 2004).”
Xist nucleates local protein gradients to propagate silencing across the X chromosome (2021, background): “Since PRC1 is critical for chromatin compaction in various developmental contexts (Boyle et al., 2020; Francis et al., 2004; Grau et al., 2011; Illingworth, 2019), we explored whether the B-repeat is required for the structural reorganization of the Xi.”
Transcriptional regulation by Polycomb group proteins (2013, background): “; and from the Novo Nordisk Foundation, the Danish Cancer Society and the Danish Council for Strategic Research (12-110503) to K.”
Multivalent engagement of chromatin modifications by linked binding modules (2007, background): “Effector proteins may alter the properties of chromatin by crosslinking two or more nucleosome”
PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes (2012, methodology): “…chromodomain-containing protein that binds to H3K27me3 (Fischle et al., 2003; Min et al., 2003); dRing, the enzyme responsible for H2A ubiquitination (Wang et al., 2004); Posterior sex combs (Psc), which is responsible for chromatin compaction in vitro (Francis et al., 2004); and Polyhomeotic (Ph).”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, positive): “…the lysine 119 of histone H2A (H2AK119ub1), which was proposed to consolidate transcriptional repression by preventing access to chromatin remodelers, inhibiting RNA polymerase II-dependent transcriptional elongation and facilitating chromatin compaction (Francis et al., 2004; Zhou et al., 2008).”
Polycomb silencers control cell fate, development and cancer (2006, background): “In vitro , PRC1 was found to bind nucleosome arrays even if the N-terminal histone tails have been removed by tryptic digestio”