Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

By C. Toyoshima, M. Nakasako, H. Nomura, H. Ogawa. Nature, 2000

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How researchers see this paper

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Biology, structure and mechanism of P-type ATPases (2004, background): “The SR Ca 2+ -ATPase has become the archetype of the P-type-ATPase family, because its atomic structure is the only one so far to have been determined experimentall”
Artemisinins target the SERCA of Plasmodium falciparum (2003, background): “The recent structural solution of mammalian SERCAs will aid in understanding selective toxicity of artemisinins and in producing congener”
Large-scale analysis of the yeast proteome by multidimensional protein identification technology (2001, background): “The crystal structure of Ca 2+ -ATPase from sarcoplasmic reticulum, a P-type ATPase, has recently been determine”
What vibrations tell about proteins (2002, background): “A comparison of two Ca2+-ATPase structures (Toyoshima et al. 2000 ; Toyoshima & Nomura, 2002) shows that much of the conformational change can be explained by rigid domain movements, kinking of helices or movements of helices relative to others.”
P-Type ATPases (2016, background): “Well established dyes in studies with P-type ATPases are: cationic carbocyanines, such as DiIC1(5) [7] or DiSC3(5) [9, 13, 15], and anionic oxonol dyes, especially Oxonol VI [16–18].”
Calcium: Phospholamban: a crucial regulator of cardiac contractility (2003, background): “Transmembrane helices M4 and M6 also contribute strongly to Ca 2+ bindin”