Artemisinins target the SERCA of Plasmodium falciparum
By U. Eckstein-Ludwig, R. Webb, I. V. Goethem, J. East, Anthony G. Lee, M. Kimura, P. O’Neill, P. Bray, S. Ward, S. Krishna. Nature, 2003
1,017 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Epidemiology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/4efd7124122d2049798be83a406b279f36c7b145
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In Epidemiology
In Public Health, Environmental and Occupational Health
Citations in the corpus
- Antimalarial drug resistance. (2004, background): “Although the target for the artemisinins has recently been identified (PfATPase6) (22), preliminary studies have not so far associated polymorphisms in the gene encoding this enzyme with reduced susceptibility to artemisinins (18).”
- Dietary inclusion of dried Artemisia annua leaves for management of coccidiosis and growth enhancement in chickens (2008, background): “mechanism of action based on inhibition of sarcoplasmic endoplasmic reticulum calcium ATPase (SERCA) of Plasmodium has been suggested (Eckstein-Ludwig et al., 2003), which has reconciled some intriguing observations on the actions of artemisinins against the parasite (Woodrow et al.”
- Molecular understanding and modern application of traditional medicines: triumphs and trials. (2007, background): “…has identified numerous cellular constituents alkylated by artemisinin (Asawamahasakda et al., 1994); the strongest validated target for artemisinin is PfATP6, the Plasmodium sarco-endoplasmic reticulum Ca2+ ATPase (SERCA), which is inhibited by artemisinin (Eckstein-Ludwig et al., 2003).”
- Target identification with quantitative activity based protein profiling (ABPP) (2017, background): “4) and its derivatives, as the most potent antimalarial drugs [87,88], have been intensively studied for decades with several proteins having been reported as potential drug target candidates [89–91].”
- Guidelines for the treatment of malaria (2010, background): “Artemisinin and its derivatives inhibit an essential calcium adenosine triphosphatase, PfATPase 6 (29).”