The adult Drosophila posterior midgut is maintained by pluripotent stem cells

By B. Ohlstein, A. Spradling. Nature, 2006

1,099 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Insect Science

View Paper: https://www.semanticscholar.org/paper/f76b78c28e94d0c8ab16494749cd6e4aef255434

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Nusse
2. Juergen A. Knoblich
3. D. L. Jones
4. N. Broderick
5. A. Wagers
6. D. Scadden
7. C. Logan
8. Sveta Chakrabarti

In Immunology

1. Nicolas Buchon
2. R. Nusse
3. Juergen A. Knoblich
4. D. L. Jones
5. Bruce Edgar
6. Parthive H. Patel
7. N. Broderick
8. D. McEwen

In Insect Science

1. Nicolas Buchon
2. Juergen A. Knoblich
3. N. Broderick
4. D. Scadden
5. Sveta Chakrabarti
6. B. Lemaître

Citations in the corpus

• Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver (2015, background): “By maintaining a diploid genome, the pericentral cells would, like stem cells do[25], retain unlimited replicative potential.”
• No place like home: anatomy and function of the stem cell niche (2008, background): “melanogaster , which maintain the intestinal epithelium and generate both polyploid enterocytes as well as hormone-producing enteroendocrine cell”
• The stem-cell niche as an entity of action (2006, background): “Two reports have demonstrated that the posterior mid-gut populations of cells in Drosophila have the capacity to produce daughter cells of at least two types: enterocytes and enteroendocrine cell”
• Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. (2009, methodology): “The marked lineage system developed by Harrison and Perrimon (1993) was used to generate clones of lacZ-expressing cells ( Ohlstein and Spradling 2006 ).”
• Mechanisms of asymmetric stem cell division. (2008, background): “The striking discovery of stem cell lineages in the adult Drosophila gut (Micchelli and Perrimon, 2006; Ohlstein and Spradling, 2006), malpighian tubules (Singh et al.”
• Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. (2009, background): “The adult Drosophila midgut also contains multipotent ISCs, and it was suggested that ISCs respond to signals emitted by surrounding epithelial cells to produce appropriate daughter cells (Micchelli and Perrimon, 2006; Ohlstein and Spradling, 2006).”
• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut (2009, methodology): “Next, we applied assays of Delta/Notch signaling, which is essential for differentiation of EBs to the EC fate (Micchelli and Perrimon, 2006; Ohlstein and Spradling, 2006, 2007).”