Developmentally Regulated piRNA Clusters Implicate MILI in Transposon Control

By Alexei Aravin, Ravi Sachidanandam, Angélique Girard, Katalin Fejes-Toth, Gregory J. Hannon. Science, 2007

1,060 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f761038f5921271b6e91bd0864e290636764027e

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Citations in the corpus

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice (2008, methodology): “A subset of prepachytene piRNAs in mouse ( Aravin et al., 2007b ) and a substantial fraction of Drosophila piRNAs (Brennecke et al., 2007) are generated by a mechanism that depends upon the endonuclease activity of Piwi proteins and that is referred to as the ping-pong amplification cycle.”
Distinguishing protein-coding and noncoding genes in the human genome (2007, background): “In post-pubescent mammalian testis, piRNAs arise from dense strand-biased clusters whose biogenesis and functions remain largely unknown, although roles in transposon defense are supported for piRNAs that are expressed in germ cell precursors earlier in development (Aravin et al. 2007a).”
Non-coding RNAs in human disease (2011, background): “piRNAs are ncRNAs of 24–30 nt in length, are Dicer-independent and bind the PIWI subfamily of Argonaute family proteins that are involved in maintaining genome stability in germline cell”
Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer (2009, positive): “PIWIs have been reported to suppress retrotransposition, including LINE-1 element during spermatogenesis ( Aravin et al., 2007 ), but more recent studies have also implicated its role in somatic organs (Malone et al., 2009).”
Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary (2009, background): “Signatures of the ping-pong cycle are conserved throughout animals, suggesting that it is a fundamental property of the piRNA pathway (Aravin et al., 2007b; Houwing et al., 2007; Murchison et al., 2008).”
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (2008, methodology): “All mapped sequences were also searched against the currently known human piRNAs (Aravin et al. 2007) using sequences retrieved from piRNABank (Lakshmi and Agrawal 2007).”
Epigenetic events in mammalian germ-cell development: reprogramming and beyond (2008, background): “Recently, a link between a small-RNA pathway and DNA methylation of retrotransposons was discovere”
Establishing, maintaining and modifying DNA methylation patterns in plants and animals (2010, background): “However, subsequent analyses of piRNA populations isolated at earlier stages of mouse development revealed an enrichment in repetitive DNA sequence”