COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

By N. Chandrasekharan, H. Dai, K. Roos, N. Evanson, Joshua Tomsik, T. Elton, D. Simmons. Proceedings of the National Academy of Sciences of the United States of America, 2002

2,002 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/f6cfce0f39ec96e24d079308022b1f08c57ed97e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hanna Achache
2. C. Harris
3. A. Revel

In Pharmacology

1. P. Rao
2. C. Harris
3. E. Knaus

Citations in the corpus

• The Immunomodulatory and Anti-Inflammatory Role of Polyphenols (2018, background): “Cyclooxygenase (COX) or lipoxygenase (LOX) metabolize it and produce, respectively, prostaglandins (PGs) and thromboxane A2 (TXA2) by COX, and hydroxyeicosatetraenoic acids and leukotrienes (LTs) by LOX [106].”
• Selective COX-1 inhibition: A therapeutic target to be reconsidered. (2010, background): “They also showed that COX-3 was putatively the specific target of acetaminophen [3].”
• Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. (2008, background): “with the discovery of a third isoform COX-3 by Simmons and coworkers (76).”
• Paracetamol: new vistas of an old drug. (2006, background): “In rodents and humans COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity, so that it is improbable that COX-3 in these species plays a role in prostaglandin-mediated fever and pain (see for a review: 112).”
• Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004, background): “2-kb COX-1 mRNA in cerebral cortex, other regions of the forebrain, heart, and muscle can contain all or part of intron-1 and is the human analog of the COX-3 mRNA in dog (Chandrasekharan et al., 2002).”
• Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic (2004, background): “It has been suggested recently that there is another COX enzyme formed as a splice variant of COX-1 (13).”
• Anti-Inflammatory Action and Mechanisms of Resveratrol (2021, background): “AA is released by membrane phospholipids with the cleavage of phospholipase A2, and then metabolized by COX with generation of PGs (such as PGD2, PGE2, PGI2) and thromboxane (TX) A2 [53] (Figure 2).”
• Endometrial receptivity markers, the journey to successful embryo implantation. (2006, background): “To date, three isoforms of COX have been reported, COX-1, COX-2 and COX-3 (Smith and Dewitt, 1996; Vane et al., 1998; Chandrasekharan et al., 2002).”
• Cyclooxygenase‐2 (COX‐2) in Inflammatory and Degenerative Brain Diseases (2004, background): “Thus, COX-3 could represent the brain-specific COX isoform, the existence of which was hypothesized a few decades ago to explain the potent analgesic and antipyretic actions of paracetamol in spite of its poor ability to inhibit COX from peripheral tissues ( 12 ).”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “The PTGS1 gene encodes for both COX-1 and COX-3 isoenzymes; however, COX-3 activity in humans remains unclear [177, 178].”
• Radical causes of cancer (2003, background): “Recently, a third member of the cyclooxygenase family, COX3, has been cloned and characterize”
• The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. (2009, background): “A third form (COX-3) has also been reported [15], although recent studies indicate that this represents a splice variant of COX-1 that encodes a truncated protein lacking enzymatic activity [16].”