Cyclooxygenase‐2 (COX‐2) in Inflammatory and Degenerative Brain Diseases

By L. Minghetti. Journal of Neuropathology and Experimental Neurology, 2004

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A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. (2011, background): “COX-2 is stimulated by pro-inflammatory cytokines and lipopolysaccharide (LPS) (Dubois et al., 1998; Minghetti, 2004) and participates in the synthesis of prostanoids, like PGE2 (Smith et al.”
A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information (2017, neutral): “In addition, the COX proteins provide a class of important targets in a wide range of inflammatory diseases [40].”