[Induction of direct antimicrobial activity through mammalian toll-like receptors].

By S. Thoma-Uszynski, S. Stenger, O. Takeuchi, M. Ochoa, Matthias Engele, P. Sieling, P. Barnes, M. Röllinghoff, P. Bölcskei, M. Wagner and 6 more. Pneumologie, 2001

808 citations recorded by the source corpus.

Subfields: Immunology, Parasitology

View Paper: https://www.semanticscholar.org/paper/f6b8642a77a17389fd08b125c6a6977f3c7ac699

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. K. Takeda
4. TA Wynn
5. Katherine A. Fitzgerald
6. T. Kaisho
7. Taro Kawai
8. T. Kanneganti

In Parasitology

1. TA Wynn
2. R. Medzhitov

Citations in the corpus

• Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens (2008, background): “TLR and interferon pathways synergistically trigger NO production by transcriptional and post-transcriptional mechanisms that enhance expression of inducible nitric oxide synthase (iNOS), the enzyme responsible for NO production from arginine in macrophage”
• Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence (2003, background): “When M. tuberculosis enters macrophages and other phagocytic cells, this surface-exposed glycolipoprotein is thought to cause host signaling events as it interacts with TLR2 (201, 287).”
• Innate Immunity to Mycobacterium tuberculosis (2002, neutral): “tuberculosis in alveolar macrophages in vitro (222).”
• Toll-like receptors. (2003, background): “TLR2 activation leads to nitric oxide–dependent and –independent killing of intracellular Mycobacterium tuberculosis in mouse and human macrophages, respectively (278).”
• Toll-like receptors and innate immunity (2001, background): “Mammalian TLRs also induce multiple effector molecules such as inducible nitric oxide synthase and antimicrobial peptides, which can directly destroy microbial pathogen”
• Nitric oxide and the immune response (2001, background): “Among viral and microbial products, the HTLV-I transactivator Tax, the 19-kD lipoprotein of Mycobacterium tuberculosis (acting via Toll-like receptor (TLR)-2), the flagellin of Gram-negative bacteria (acting via TLR-5), the effector protein SopE2 of Salmonella typhimurium , bacterial DNA and ”
• Pathogen recognition and innate immunity. (2006, neutral): “tuberculosis that is also a potent cytokine inducer of macrophages (Thoma-Uszynski et al., 2001), and TLR9 can be activated by mycobacterial DNA, which may be released during endolysosomal degradation.”
• Toll-like receptors: critical proteins linking innate and acquired immunity (2001, background): “tuberculosis but also initiates the killing of these organism”
• Recognition of microorganisms and activation of the immune response (2007, background): “In mouse macrophages, the activation of TLRs results in transcription of the gene encoding inducible nitric-oxide synthase (iNOS; also known as NOS2), which has an important role in antimicrobial defenc”