Toll-like receptors and innate immunity

By R. Medzhitov. Nature reviews. Immunology, 2001

2,582 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/8d56741b059eeb41ddfead580647cc879769b68e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. C. Garlanda
3. K. Karikó
4. M. Karin
5. Michael R. Irwin
6. George M. Slavich
7. D. Weissman
8. J. O’Shea

In Microbiology

1. Christopher Weidenmaier
2. A. Peschel
3. M. Karin
4. L. Romani
5. Michael R. Irwin
6. C. Shi
7. Shijun Li
8. Zhiwen Fu

Citations in the corpus

• Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response (2002, background): “fumigatus because this fungus is a major pathogen in immunodeficient individuals, and pattern-recognition receptors that have a non-redundant role in vivo against fungal infections of mammals have not yet been describe”
• Acute Chorioamnionitis and Funisitis: Definition, Pathologic Features, and Clinical Significance (2015, background): “Once microorganisms gain access to the fetal mucosa, they are recognized by pattern recognition receptors such as Toll-like receptors, and ligation of such receptors can induce the deactivation of transcription factors such as NFkB and elicit a localized (and subsequently systemic) inflammatory resp”
• Antibody drug conjugate: the “biological missile” for targeted cancer therapy (2022, methodology): “For example, activation of TLR7 and/or TLR8 could induce MyD88 dependent signaling pathway that activate NF-κB for the secretion of cytokines and chemokines, allowing infiltration of anti-tumor lymphocytes.(82) BDC-1001 is a Boltbody ISAC that is currently in clinical development (Phase 1/II, NCT042”
• The biology of IL-12: coordinating innate and adaptive immune responses. (2003, background): “[22] Medzhitov R.”
• Research Progress on the Relationship between Atherosclerosis and Inflammation (2018, background): “Toll-like receptor 4 (TLR4), a typical representative of pattern recognition receptors in innate immune responses, which can activate the transcription factors nuclear factor-κB (NF-κB) leading to the production of proinflammatory cytokines [49].”