Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.

By P. Scheiffele, Jinhong Fan, J. Choih, R. Fetter, T. Serafini. Cell, 2000

1,233 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/f660d23963613e0e3ff827f8d372eac68ec8e55b

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Citations in the corpus

EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. (2000, positive): “Alternatively, ephrinB may function in concert with other factors such as wnts or neuroligins that then Imaging promote the maturation of pre- and postsynaptic speImages were acquired using a Noran OZ Confocal System on a cializations (Hall et al., 2000; Scheiffele et al., 2000).”
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. (2007, neutral): “NLs, when expressed in nonneuronal cells, induce formation of synapses by cocultured neurons, probably via a trans-synaptic interaction with presynaptic a- and b-neurexins (Scheiffele et al., 2000; Chubykin et al., 2005; Boucard et al., 2005; Chih et al., 2006).”
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. (2012, background): “Although evidence about the functional roles of NLGNs and NRXNs initially came from coculturing experiments showing that expression of these proteins in nonneuronal cells can induce presynaptic and postsynaptic specialization, respectively (Scheiffele et al. 2000; Graf et al. 2004; Nam and Chen 2005”
Extracellular Domains of α-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+ Channels (2005, background): “Because of the high Ca 2 cooperativity and Ca 2 sensitivity of neurotransmitter release (Bollmann et al., 2000; Schneggenburger and Neher, 2000), regulating VDCCs efficiently controls synaptic strength, and small changes in Ca 2 influx lead to magnified effects on synaptic release (Felmy et al.,…”
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis (2003, neutral): “, which are thought to perform important functions in shaping synapse”
Acetylcholinesterase — new roles for an old actor (2001, background): “This phenomenon was prevented by the addition of the extracellular domain of β-neurexin, a binding partner of neuroligi”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “SynCAM and neuroligins are the only cell adhesion molecules that promote presynaptic differentiation at contacts between axons and heterologous cells, and drive the recruitment of synaptic proteins at the sites of contact (Biederer et al., 2002; Dean et al., 2003; Scheiffele et al., 2000).”
Neurexin mediates the assembly of presynaptic terminals (2003, background): “Non-neuronal HEK293 cells that ectopically express neuroligin-1 or neuroligin-2 trigger the formation of functional presynaptic elements in contacting axons in vitro”
Cell adhesion molecules: signalling functions at the synapse (2007, background): “In addition, neuroligin-expressing non-neuronal cells co-cultured with neurons induce presynaptic differentiation of contacting axon”
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. (2004, background): “The HA-tagged neuroligins-1 and -2 (gift from P. Scheiffele; Scheiffele et al., 2000) both contain the neuroligin-1 signal sequence followed by the HA tag (YPYDVPDYA) and the mature N terminus of each of the neuroligins inserted into the pNice expression vector.”