EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.

By M. Dalva, M. Takasu, Michael Z. Lin, S. Shamah, Linda S. Hu, N. Gale, Michael E. Greenberg. Cell, 2000

707 citations recorded by the source corpus.

EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB. The kinase activity of EphB may be important for subsequent steps in synapse formation, as perturbation of EphB tyrosine kinase activity affects the number of synaptic specializations that form in cultured neurons. These findings indicate that EphrinB activation of EphB promotes an association of EphB with NMDA receptors that may be critical for synapse development or function.

Subfields: Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/7f9e17e0460f7dc7557182180848888e1fa6197a

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Citations in the corpus

Cell adhesion molecules: signalling functions at the synapse (2007, background): “Localization experiments along with functional studies indicate that EphB2 is primarily found in postsynaptic terminals in the hippocampus and cortex during synaptogenesi”
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. (2008, background): “EphB receptors play important roles in synapse development and function, and during development, contact between postsynaptic EphB receptors and presynaptic ephrins may induce the association of NMDA receptors with EphB receptors (Dalva et al., 2000).”
Wnts and TGFβ in synaptogenesis: old friends signalling at new places (2003, background): “Recent evidence indicates that other sets of secreted molecules, such as EPHRINS”
Multiple roles of eph receptors and ephrins in neural development (2001, background): “and emerging evidence that they have roles in synaptic plasticity, learning and memor”
Neurexin-neuroligin signaling in synapse development. (2007, background): “Complementary studies on SynCAMs [53], ephrins and Eph receptors [54], synaptic adhesion-like molecules [55,56] and netrin-G ligands [57] indicate that additional cell adhesion molecules are specific for glutamatergic as opposed to GABAergic synapses, and that these molecules can also link to postsy”
Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “…al., 2007) and neuronal pentraxins (NARP and NP1) for AMPA receptors (O’Brien et al., 1999; Sia et al., 2007) the ephrin receptor for NMDA receptors (Dalva et al., 2000; Takasu et al., 2002); cerebellin1 precursor protein for GluD2 receptors (Matsuda et al., 2010; Uemura et al., 2010; see also…”
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity (2009, positive): “The kinase activity of EphBR is not required for the initial clustering of NMDAR at the synapse but is essential for their maintenance.(61) Stimulation of EphBR potentiates NMDAR-induced Ca(21) influx and the phosphorylation of CREB through the activation of the nonreceptor tyrosine kinase src(314) ”
Developmental cell biology: Eph receptor signalling casts a wide net on cell behaviour (2005, background): “Additionally, clustering of EphB receptors by ephrins drives the assembly of synaptic components such as neurotransmitter receptors and cytoplasmic PDZ-domain-containing proteins in cultured neuron”
Mechanisms and functions of eph and ephrin signalling (2002, background): “Although the interaction is independent of EphB kinase activity, the authors showed that subsequent steps of synapse formation in neuronal cell cultures require EphB kinase activit”
Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease (2007, background): “These two synaptic receptors physically interact via their extracellular domains (Dalva et al., 2000) and are functionally related to plasticity.”
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. (2004, background): “Ephrins binding to EphB receptors can promote NMDA receptor aggregation and spine maturation (Dalva et al., 2000; Henkemeyer et al., 2003) but do not induce clustering of scaffolding proteins such as PSD-95 that normally cluster at developing synapses prior to receptors (Friedman et al.”
Src kinases: a hub for NMDA receptor regulation (2004, background): “EphB receptors interact directly with NMDARs in cultured neuron”
Balancing structure and function at hippocampal dendritic spines. (2008, background): “EphB receptors directly associate with NMDA receptors at synapses, and ephrinBinduced activation of EphB receptors causes NMDA receptor clustering (Dalva et al. 2000).”