Neurexin mediates the assembly of presynaptic terminals

By Camin Dean, F. Scholl, J. Choih, Shannon DeMaria, J. Berger, E. Isacoff, P. Scheiffele. Nature Neuroscience, 2003

610 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6221285a5663cb7e84b645375f6c1a7dbf0cfeca

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Citations in the corpus

X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. (2004, background): “Dean et al. (2003) demonstrated that two alpha helices located at the base of the AchE-homologous domain of NLGN1 were critical for interaction between other neuroligins, with inactivating amino acid mutations that affect multimerization and reduce the synapsepromoting activity of the protein.”
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. (2007, neutral): “NL1-Induced Increase in Synapse Numbers Requires NMDAR Signaling To test whether the increase in synapse numbers induced by overexpression of NL1 (Dean et al., 2003; Graf et al., 2004; Chih et al., 2006; Prange et al., 2004; Levinson et al., 2005) is constitutive or involves synaptic signaling, we o”
Structural Components of Synaptic Plasticity and Memory Consolidation. (2015, background): “This extracellular binding modulates presynaptic vesicle release and promotes synapse initiation and stabilization together with N-cadherin (Ichtchenko et al. 1995; Song et al. 1999; Scheiffele et al. 2000; Dean et al. 2003; Graf et al. 2004; Futai et al. 2007; Heine et al. 2008; Sudhof 2008; deWit ”
Polymer-supported membranes as models of the cell surface (2005, methodology): “For example, planar supported membranes were used in a study that used membranes containing GPI-anchored neuroligin on silica particles to show that the clustering of β-neuroligin is sufficient to trigger the recruitment of synaptic vesicle”
PDZ domain proteins of synapses (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=20969">syndecan and SynCA”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “SynCAM and neuroligins are the only cell adhesion molecules that promote presynaptic differentiation at contacts between axons and heterologous cells, and drive the recruitment of synaptic proteins at the sites of contact (Biederer et al., 2002; Dean et al., 2003; Scheiffele et al., 2000).”
Neurexin-neuroligin signaling in synapse development. (2007, background): “Triggers of presynaptic and postsynaptic differentiation Neuroligins presented alone on the surface of nonneuronal cells or beads induce localized formation of functional release sites in axons, by aggregating neurexins on the axon surface [2,16].”
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. (2004, background): “Moreover, antibody-induced clustering of recombinant neurexin directly induced the coclustering of synaptic vesicles (Dean et al., 2003).”
Extracellular Domains of α-Neurexins Participate in Regulating Synaptic Transmission by Selectively Affecting N- and P/Q-Type Ca2+ Channels (2005, background): “…and Craig laboratories suggests, as originally proposed when neurexins were first identified (Ushkaryov et al., 1992), that neurexins can promote the formation of de novo synapses and differentiation of postsynaptic receptors (Scheiffele et al., 2000; Dean et al., 2003; Graf et al., 2004).”
Neuroligins determine synapse maturation and function. (2006, neutral): “…Prange et al., 2004; Scheiffele et al., 2000) and the proposed role of NLs in the synaptic recruitment of glutamate receptors (Chih et al., 2005; Dean et al., 2003; Graf et al., 2004; Levinson et al., 2005; Nam and Chen, 2005; Prange et al., 2004; Scheiffele et al., 2000; Serafini, 1999) we had…”
Cell adhesion molecules: signalling functions at the synapse (2007, background): “The synaptogenic activity of neuroligins depends on lateral ( cis ) clustering of neuroligin molecules, which requires the presence of particular amino acids located in the neuroligin esterase-like ectodomai”