Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling.

By K. Irani. Circulation Research, 2000

790 citations recorded by the source corpus.

Subfields: Biochemistry, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/f65858d1aeeb799447273d43bdec31f76f434b29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. A. Shah
2. Jian-Mei Li
3. Rhian M. Touyz

In Immunology

1. A. Shah
2. T. Fukai
3. Jian-Mei Li
4. S. Dikalov
5. Rui‐Ming Liu
6. L. Desai

In Physiology

1. S. Dikalov
2. A. Shah
3. T. Fukai
4. Jian-Mei Li
5. Rhian M. Touyz
6. U. Förstermann
7. Rui‐Ming Liu
8. L. Desai

Citations in the corpus

• A review of the interaction among dietary antioxidants and reactive oxygen species. (2007, background): “Additionally, ROS levels influence the accumulation and hypertrophy of vascular smooth muscle cells (VSMC) observed in atherosclerotic, restenotic lesions and hypertensive vascular diseases [93].”
• Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. (2003, background): “Nitric oxide inhibits vascular smooth-muscle cell proliferation (9, 10), whereas ROSs stimulate smooth-muscle cell growth (8, 45).”
• Diabetes associated cell stress and dysfunction: role of mitochondrial and non‐mitochondrial ROS production and activity (2007, background): “The involvement of ‘non-damaging’ levels of ROS in signal transduction is now firmly accepted and examples include roles in cell growth or programmed cell death (apoptosis) (Burdon, 1995; Irani et al. 1997; Irani, 2000), kinase activation (Lu, 1993; Lo et al.”
• The effects of oxidative stress on female reproduction: a review (2012, background): “Reactive oxygen species do not always directly target the pathway; instead, they may produce abnormal outcomes by acting as second messengers in some intermediary reactions [48].”
• Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, neutral): “The role of ROS in signaling has been reviewed extensively (47, 49, 50, 52, 63, 64, 66, 87, 99, 138, 162, 187, 190, 191, 195, 197, 217, 222).”
• Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. (2004, background): “More detailed reviews of redox signaling mechanisms were published recently (29, 38, 71, 80, 82).”