Hypothalamic regulation of sleep and circadian rhythms

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Alerting effects of light. (2007, background): “Through as yet unidentified pathways, light stimulates the ascending arousal system and eventually the cortex to enhance alertness and cognition.(69) In this context, two brain regions are of particular interest: the ventrolateral preoptic nucleus (VLPO) in the anterior hypothalamus and the locus co”
Neuromodulation of brain states. (2012, neutral): “Several studies have identified groups of GABAergic neurons in the ventrolateral preoptic area (VLPO) and median preoptic nucleus (MnPO) as sleeppromoting cells (Saper et al., 2005; Sherin et al., 1996; Szymusiak and McGinty, 2008).”
On the role of phylogeny in determining activity patterns of rodents (2006, background): “At a time where we have increased dramatically our understanding of the proximate mechanisms controlling activity patterns of animals (e.g. Antle and Silver 2005; Saper and Scammell 2005; Saper et al. 2005), we still have little understanding of”
The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “1 ), and these output pathways are responsible for proper timing of hormone release, feeding behaviour and body-temperature fluctuation”