The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

By S. Youssef, O. Stüve, J. Patarroyo, P. Ruiz, J. Radosevich, E. Hur, M. Bravo, D. Mitchell, R. Sobel, L. Steinman and 1 more. Nature, 2002

1,158 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/f63a6b2d3d73f4406ad349d1afb0063a9da36f75

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Citations in the corpus

Immunology of multiple sclerosis. (2005, neutral): “Promising results have also been observed with estriols (51) and the cholesterin-lowering statins (351, 352).”
Minocycline: far beyond an antibiotic (2013, background): “Minocycline was also effective in combination with atorvastatin, a statin previously reported to be effective in attenuating clinical EAE in mice (Youssef et al., 2002).”
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. (2006, background): “The first experimental studies from Dr Steinman’s group (Youssef et al., 2002) were soon followed by work pointing at microglial activation by lipid degradation products, downregulated by statin activity (Aktas et al.”
Statin therapy in autoimmunity: From protein prenylation to immunomodulation (2006, background): “Although these observations indicated that statins inhibit MHC class II upregulation through selective inhibition of expression from the IFNγ-inducible CIITA-promoter pIV, more recent data indicate that statins also inhibit IFNγ-inducible CIITA expression from pI, indicating that statins are not sel”
Multiple sclerosis: a complicated picture of autoimmunity (2007, background): “; the possible mechanisms encompass many steps in T cell activation as well as immunoregulatory processes, including a shift from a proinflammatory environment to the production of anti-inflammatory cytokine”
The immune response in atherosclerosis: a double-edged sword (2006, neutral): “and in mice with experimental autoimmune encephalomyeliti”
Statins and cancer prevention (2005, background): “Activation of NF-κB, which promotes T H 1 development, can also be inhibited by atorvastati”
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. (2008, background): “Statins prevent experimental T helper 1 (Th1)-mediated autoimmune diseases [95] and induce IL-4-dependent Th2-cell differentiation [96] and the secretion of antiinflammatory Th2-type cytokines [97].”
Experimental autoimmune encephalomyelitis repressed by microglial paralysis (2005, background): “Immunomodulatory compounds, including IFN-β, copolymer I and statins, can repress CNS autoimmune diseases including EA”
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, neutral): “Statins (Youssef et al., 2002) (Vollmer et al.”