Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.

By M. Nordsmark, Søren Bentzen, V. Rudat, D. Brizel, E. Lartigau, P. Stadler, A. Becker, M. Adam, M. Molls, J. Dunst and 2 more. Radiotherapy and Oncology, 2005

942 citations recorded by the source corpus.

Subfields: Cancer Research, Otorhinolaryngology, Radiation

View Paper: https://www.semanticscholar.org/paper/f636a7ae8132840fc31466b950bdf3a4aff02b94

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Mayer
2. P. Vaupel
3. J. Overgaard
4. M. Höckel
5. R. Hill
6. S. Påhlman
7. Michael Baumann
8. Mechthild Krause

In Otorhinolaryngology

1. Adrian C. Begg
2. F. Stewart
3. Conchita Vens

In Radiation

1. Adrian C. Begg
2. F. Stewart
3. Conchita Vens

Citations in the corpus

• Hypoxic radiosensitization: adored and ignored. (2007, background): “Concerning the relationship between hypoxia and outcome after radiotherapy, there are numerous studies, especially in squamous cell carcinomas, indicating that hypoxic tumors do have a significantly poorer outcome than tumors that express less hypoxic features.(3,16,19,21) However, it should be made”
• Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. (2013, background): “Many tumours are comprised of poorly oxygenated hypoxic regions that are chemo- and radio-resistant [71] and patients displaying highly hypoxic tumours have a much poorer outcome than those with well-oxygenated tumours [72].”
• Detection and Characterization of Tumor Hypoxia Using pO2 Histography (2007, positive): “An updated summary of all major studies on the oxygenation status of head and neck cancers and on the relationship be-tween pretreatment pO 2 measurements and survival in advanced tumors after primary radiotherapy has been published recently (96).”
• Exploring the role of cancer stem cells in radioresistance (2008, background): “The observation that some biomarkers, including measures of tumour hypoxi”
• Hypoxia in cancer: significance and impact on clinical outcome (2007, background): “[30] involving 397 patients with head & neck tumors provided further evidence that tumor hypoxia is associated with a poor prognosis in patients with advanced head & neck cancer following primary radiotherapy.”
• Targeting hypoxia in cancer therapy (2011, background): “The need to quantify (not just to detect) hypoxia is illustrated by a meta-analysis of oxygen-electrode studies, which suggested that hypoxia compromised overall survival in patients with advanced HNSCC undergoing chemoradiation treatment but only in the subset of patients with the most extensive hy”
• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. (2010, background): “The percentage of viable tumor cells within individual tumors with otherwise similar clinical features varies tremendously among patients (2) and is clinically important because high levels of tumor hypoxia correlate with poor prognosis and a more aggressive phenotype (2–6).”
• Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, result): “Patients with hypoxic head and neck tumors (Gatenby et al., 1988; Nordsmark et al., 2005), cervical cancer (Hockel et al., 1993; Hockel et al., 1996), and soft tissue sarcoma (Nordsmark et al., 2001) had a worse prognosis, although some results are conflicting (Nordsmark et al., 2006).”
• Strategies to improve radiotherapy with targeted drugs (2011, background): “Three main biological factors of tumours have been shown to affect outcome after radiotherapy: the extent of hypoxia”