Hypoxic radiosensitization: adored and ignored.

By J. Overgaard. Journal of Clinical Oncology, 2007

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The impact of O2 availability on human cancer (2008, background): “However, these approaches did not gain widespread use owing to conflicting reports of their efficacy in clinical trial”
Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability (2008, background): “In general, clinical trials that have attempted to decrease tumour hypoxia with these and other drugs have significantly improved local control and overall survival, indicating that for many tumours hypoxia affects treatment outcome despite reoxygenation during fractionated therap”
Exploring the role of cancer stem cells in radioresistance (2008, background): “This indicates that a fraction of the cancer stem cells is protected from the effects of radiation by hypoxia, which is supported by experimental and clinical studies showing that this protection may be reduced by hypoxic cell sensitizers or oxygen-enriched breathing gase”