Targeting hypoxia in cancer therapy

By William R. Wilson, Michael P. Hay. Nature Reviews. Cancer, 2011

2,914 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/48a13f9a47121f3f64b427c525d9a46ec45ebad2

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Citations in the corpus

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions (2016, neutral): “Currently used pharmaceutical nanocarriers such as liposomes, micelles, polymeric nanoparticles and many others, generally fail to reach these hypoxic regions 8 .”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “Therefore, either directly targeting hypoxia or the factors promoting this important phenomenon is an emerging form of therapy under investigation [162, 163].”
ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, neutral): “Palazón et al., 2012; Semenza, 2014; Wilson and Hay, 2011).”
T Cell Dysfunction in Cancer (2018, background): “This creates an environment with low glucose, low amino acids, low oxygen, and low pH, which are all considered metabolic checkpoints (Kato et al., 2013; Martinez-Outschoorn et al., 2017; Scharping and Delgoffe, 2016; Wilson and Hay, 2011).”
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors (2012, background): “Furthermore, a harsh hypoxic and acidic microenvironment imposes a survival advantage for more malignant cancer cells, harbors the so-called cancer-initiating cells, confers resistance to cell death by apoptosis and autophagy, and enhances the invasive and metastatic potential of cancer cells (54).”
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “Hypoxia also confers resistance because various treatments, such as radiation, certain chemotherapies, photodynamic therapy, and even immunotherapies, require oxygen to be effective.(43,44,48,49) Because of their excessive leakiness, tumor vessels are unable to maintain pressure gradients across the”
Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Cancer-associated fibroblasts(CAFs) are vital constituents of the tumor microenvironment, and their interactions with cancer cells play a major role in mediating their formation and activation [28, 29].”
Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “conditions can result in an increase in the distance between the capillaries, exceeding the capacity of oxygen to diffuse [11, 12].”