Degradation of oxidized proteins by the 20S proteasome.

By K. Davies. Biochimie, 2001

860 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f6345dcf06ee3a57b7463bd6416cdbb5345746e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. Cuervo
2. R. Kiffin
3. E. Knecht
4. Christopher Christian
5. O. Maier
6. P. Jenner
7. Roman Fischer
8. Peter Tompa

In Epidemiology

1. A. Cuervo
2. R. Kiffin
3. E. Knecht
4. Christopher Christian
5. O. Maier
6. P. Jenner
7. Roman Fischer
8. Peter Tompa

In Molecular Biology

1. A. Cuervo
2. M. Mouradian
3. O. Maier
4. Roman Fischer
5. Peter Tompa
6. Wangang Zhang
7. V. Dias
8. D. Ahn

Citations in the corpus

• Altered proteasomal function in sporadic Parkinson's disease. (2003, background): “-Subunits directly interact with some protein substrates and regulate their translocation and degradation within the 20S proteasome core (31, 32).”
• The interplay between structure and function in intrinsically unstructured proteins (2005, background): “success of disorder-based prediction of phosphorylation sites [41] and an array of recent observations of the cleavage of non-ubiquitinated, disordered proteins, such as casein [45], tau [46] and p21 [47] by the 20S proteasome and the disorder-targeted ubiquitination of securin and cyclin B in cell ”
• The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “In addition , the amino acid products released in the process of degradation, which may become oxidized and thereby function as ROS scavengers, can protect vital cellular components from oxidation [157] [158] [159].”
• Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF (2015, background): “Nonfunctional proteins are predominantly degraded in an ubiquitination-dependent manner by the proteasome [38].”
• Activation of chaperone-mediated autophagy during oxidative stress. (2004, background): “The ability of proteasomes to degrade oxidized proteins has been previously well documented in vitro (Rivett, 1985; Davies, 2001), and more recently in vivo (Grune et al.”
• Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. (2006, background): “By inhibiting the proteasome function, these aggregated, cross-linked, and oxidized protein products of oxidative stress cause a vicious cycle of progressively worsening accumulation of cytotoxic protein oxidation products (Davies, 2001; Poppek and Grune, 2006).”
• Protein Oxidation: Basic Principles and Implications for Meat Quality (2013, background): “For instance, proline oxidation provides a unique mechanism for peptide bond cleavage via the formation of 2-pyrrolidone, which later is hydrolyzed to 4-aminobutyric acid (Stadtman, 1993; Hawkins and Davies, 2001).”