Counting the zinc-proteins encoded in the human genome.

By Claudia Andreini, L. Banci, I. Bertini, Antonio Rosato. Journal of Proteome Research, 2006

1,015 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/f62dceb764fcef055d1bff2a0a5c5e40cfb3c72b

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In Molecular Biology

1. C. Wood
2. A. Farrell
3. P. White
4. John Hammond
5. Martin R. Broadley
6. W. Maret
7. Eric P. Skaar

In Nutrition and Dietetics

1. Eric P. Skaar
2. L. Rink
3. I. Wessels
4. M. Maywald
5. P. White
6. K. Młyniec
7. Taiho Kambe
8. C. Wood

Citations in the corpus

• Matrix metalloproteinases. (2010, background): “Up to 10 % of the human proteome is potentially capable of binding zinc in vivo, with zinc-fingers being the most abundant class of metalloproteins [96,97].”
• Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “It is a component of about 10% of human proteins, including transcription factors and key enzymes regulating cellular processes and cellular signaling pathways (Rink and Gabriel 2001; Andreini et al. 2006).”
• Nutritional immunity beyond iron: a role for manganese and zinc (2009, background): “Zinc is the second most abundant transition metal within the vertebrate host and has been suggested to interact with as many as 10% of host proteins [7].”
• Zinc-Binding Cysteines: Diverse Functions and Structural Motifs (2014, background): “Recent studies estimate the human proteome consists of approximately 3000 Zn-proteins [12].”
• Zinc as a Gatekeeper of Immune Function (2017, background): “Zinc binding can be facilitated by a variety of binding motifs including: (1) zinc-finger motifs; (2) Really Interesting New Gene (RING) finger domains; (3) LIM domains composed of two adjacent zinc finger domains; and (4) plant homeodomain (PHD) domains similar to RING fingers [42].”
• The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. (2015, background): “The number of zinc proteins encoded by humans is 10% (4).”
• Homeostasis and toxicology of essential metals (2012, background): “The majority of these proteins use Zn to create folds in the protein structure (e.g. Zn fingers) or to join different gene products together (e.g. Zn hooks) (Andreini et al., 2005; Passerini et al., 2007; Maret and Li, 2009).”
• The biological inorganic chemistry of zinc ions (2016, neutral): “This is an open access article human proteins, the zinc sites of which have been predicted by bioinformatics approaches from the signature motifs in their protein sequences [1].”
• Zinc in plants. (2007, background): “2800) potentially bind Zn (Andreini et al., 2006), with hundreds more involved in Zn transport and trafficking (Beyersmann & Haase, 2001).”
• Zinc biochemistry: from a single zinc enzyme to a key element of life. (2013, background): “led to the prediction that at least 10% (w2800 gene products) of the human genome encodes zinc proteins (23).”