DREADDs for Neuroscientists
By Bryan L. Roth. Neuron, 2016
1,481 citations recorded by the source corpus.
To understand brain function, it is essential that we discover how cellular signaling specifies normal and pathological brain function. In this regard, chemogenetic technologies represent valuable platforms for manipulating neuronal and non-neuronal signal transduction in a cell-type-specific fashion in freely moving animals. Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools are now commonly used by neuroscientists to identify the circuitry and cellular signals that specify behavior, perceptions, emotions, innate drives, and motor functions in species ranging from flies to nonhuman primates. Here I provide a primer on DREADDs highlighting key technical and conceptual considerations and identify challenges for chemogenetics going forward.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/cc7db00617d97220b2f596e27279d1b9ea9bcf59
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- Progress in Brain Computer Interface: Challenges and Opportunities (2019, background): “Designer receptor exclusively activated by designer drugs, provides a chemogenetic tool to understand cell-signaling including electrical activities in molecularly clustered cell groups [139], [140].”