Control of homeostasis of CD8+ memory T cells by opposing cytokines.

By C. Ku, M. Murakami, A. Sakamoto, J. Kappler, P. Marrack. Science, 2000

961 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/f5e8926d2057152e4750c642c7fac2f4fe5a14fe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Edward J. Pearce
2. Erika L. Pearce
3. M. Bevan

In Immunology

1. Erika L. Pearce
2. M. Bevan
3. C. Surh
4. T. Malek
5. Edward J. Pearce
6. J. Sprent
7. A. Ma
8. K. Schluns

Citations in the corpus

• Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells (2002, background): “These data are in agreement with, and extend, previous experiments where antibody blocking of the IL-2/IL-15R� chain and IL-2 served to implicate IL-15 in the division of memory T cells ( 24 ).”
• IL-2, Regulatory T Cells, and Tolerance (2004, background): “Indeed, claims that IL-2 limits T cell expansion in vivo have generally been based on system-wide perturbations (33, 49, 50), which may produce unintended secondary effects.”
• Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8+ T Cell Memory Development (2011, positive): “We demonstrate that IL-15, a cytokine critical for CD8+ memory T cells (Kennedy et al., 2000; Ku et al., 2000; Mitchell et al., 2010; Sandau et al., 2010; Spleens and lymph nodes were harvested from naive and LmOVA-infected mice, and Tn, Teff, and memory T cells were isolated.”
• Cytokines in Cancer Immunotherapy (2011, background): “IL-15 also supports the persistence of memory CD8+ T cells, which may be important for maintaining long-term anti-tumor immunity [101].”
• Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor α-Chain1 (2002, background): “Most, if not all, memory CD8 cells generated in vivo are thought to express high levels of both CD44 and IL-2R (19, 20).”
• Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells1 (2002, background): “The precise mechanisms by which memory CD8 T cells survive are unknown but survival is due in part to their ability to undergo continuous low level proliferation (10) in which IL-15 may participate (11).”